@prefix np: <http://www.nanopub.org/nschema#>.
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix chear: <http://hadatac.org/ont/chear#> .
@prefix uberon: <http://purl.obolibrary.org/obo/UBERON_> .
@prefix pr: <http://purl.obolibrary.org/obo/PR_>.
@prefix hasco: <http://hadatac.org/ont/hasco#> .
@prefix uo: <http://purl.obolibrary.org/obo/UO_> . 
@prefix cst: <http://idea.rpi.edu/ontologies/cancer_staging_terms.owl#>.
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix hp: <http://purl.obolibrary.org/obo/HP_> .
@prefix dron: <http://purl.obolibrary.org/obo/DRON_> .
@prefix chebi: <http://purl.obolibrary.org/obo/CHEBI> .
@prefix db: <https://www.drugbank.ca/drugs/> .
@prefix civic-kb: <http://idea.rpi.edu/heals/kb/civic#>.
@prefix uniprot: <http://www.uniprot.org/uniprot/> .
@prefix doid: <http://purl.obolibrary.org/obo/DOID_> .
@prefix efo: <http://www.ebi.ac.uk/efo/EFO_> .


civic-kb:head-explicit_entry { 
	civic-kb:nanoPub-explicit_entry	rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-explicit_entry ;
		np:hasProvenance civic-kb:provenance-explicit_entry ;
		np:hasPublicationInfo civic-kb:pubInfo-explicit_entry .
}

civic-kb:assertion-explicit_entry {
	civic-kb:Drugs	rdf:type	owl:Class ;
		rdfs:subClassOf sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string .

	civic-kb:Status	rdf:type	owl:Class ;
		rdfs:subClassOf sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string .

	civic-kb:Evidence_ID	rdf:type	owl:Class ;
		rdfs:subClassOf sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string .

	civic-kb:Gene	rdf:type	owl:Class ;
		rdfs:subClassOf sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string .

	civic-kb:Variant	rdf:type	owl:Class ;
		rdfs:subClassOf ncit:C97927 ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string .

	civic-kb:Description	rdf:type	owl:Class ;
		rdfs:subClassOf sio:Description ;
		sio:isAttributeOf civic-kb:evidence ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string .

	civic-kb:Disease	rdf:type	owl:Class ;
		rdfs:subClassOf sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string .

	civic-kb:Evidence_Level	rdf:type	owl:Class ;
		rdfs:subClassOf ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string .

	civic-kb:Evidence_Type	rdf:type	owl:Class ;
		rdfs:subClassOf	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string .

	civic-kb:Evidence_Direction	rdf:type	owl:Class ;
		rdfs:subClassOf	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string .

	civic-kb:Clinical_Significance	rdf:type	owl:Class ;
		rdfs:subClassOf	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string .

	civic-kb:Variant_Origin	rdf:type	owl:Class ;
		rdfs:subClassOf ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating	rdf:type	owl:Class ;
		rdfs:subClassOf ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string .

}

civic-kb:provenance-explicit_entry {
	civic-kb:assertion-explicit_entry	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom civic-kb:evidence .

	civic-kb:Status
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-explicit_entry {
	civic-kb:nanoPub-explicit_entry	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime .
	civic-kb:Drugs	hasco:hasPosition	"1"^^xsd:integer .
	civic-kb:Status	hasco:hasPosition	"2"^^xsd:integer .
	civic-kb:Evidence_ID	hasco:hasPosition	"3"^^xsd:integer .
	civic-kb:Gene	hasco:hasPosition	"4"^^xsd:integer .
	civic-kb:Variant	hasco:hasPosition	"5"^^xsd:integer .
	civic-kb:Description	hasco:hasPosition	"6"^^xsd:integer .
	civic-kb:Disease	hasco:hasPosition	"7"^^xsd:integer .
	civic-kb:Evidence_Level	hasco:hasPosition	"8"^^xsd:integer .
	civic-kb:Evidence_Type	hasco:hasPosition	"9"^^xsd:integer .
	civic-kb:Evidence_Direction	hasco:hasPosition	"10"^^xsd:integer .
	civic-kb:Clinical_Significance	hasco:hasPosition	"11"^^xsd:integer .
	civic-kb:Variant_Origin	hasco:hasPosition	"12"^^xsd:integer .
	civic-kb:Trust_Rating	hasco:hasPosition	"13"^^xsd:integer .
}

civic-kb:head-virtual_entry { 
	civic-kb:nanoPub-virtual_entry	rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-virtual_entry ;
		np:hasProvenance civic-kb:provenance-virtual_entry ;
		np:hasPublicationInfo civic-kb:pubInfo-virtual_entry .
}

civic-kb:assertion-virtual_entry {
	civic-kb:evidence	rdf:type	owl:Class ;
		rdfs:label "evidence" ;
		rdfs:subClassOf ncit:C43583 .

}

civic-kb:provenance-virtual_entry {
	civic-kb:assertion-virtual_entry	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:evidence
		prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-virtual_entry {
	civic-kb:nanoPub-virtual_entry	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime .
}

civic-kb:head-f2de55ebc606800db7a1cce823db37ed {
	civic-kb:nanoPub-f2de55ebc606800db7a1cce823db37ed
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-f2de55ebc606800db7a1cce823db37ed ;
		np:hasProvenance civic-kb:provenance-f2de55ebc606800db7a1cce823db37ed ;
		np:hasPublicationInfo civic-kb:pubInfo-f2de55ebc606800db7a1cce823db37ed .
}

civic-kb:assertion-f2de55ebc606800db7a1cce823db37ed {
	civic-kb:Drugs-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-f2de55ebc606800db7a1cce823db37ed ;
		rdf:type	dron:00013025 ;
		rdf:type	db:DB0007 ;
		rdfs:label	"Trastuzumab"^^xsd:string ;
		sio:hasValue	"Trastuzumab"^^xsd:string .

	civic-kb:Status-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1453"^^xsd:integer .

	civic-kb:Gene-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C21220 ;
		rdf:type	uniprot:P42336 ;
		rdfs:label	"PIK3CA Gene"^^xsd:string ;
		sio:hasValue	"PIK3CA"^^xsd:string .

	civic-kb:Variant-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C98468 ;
		rdfs:label	"E545K"^^xsd:string ;
		sio:hasValue	"E545K"^^xsd:string .

	civic-kb:Description-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"PI3K mutant E545K was overexpressed in the trastuzumab sensitive HER2 BT474 breast cancer cell line, and significant resistance to trastuzumab was induced in comparison to control cells."^^xsd:string .

	civic-kb:Disease-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-f2de55ebc606800db7a1cce823db37ed ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-f2de55ebc606800db7a1cce823db37ed .

}

civic-kb:provenance-f2de55ebc606800db7a1cce823db37ed {
	civic-kb:assertion-f2de55ebc606800db7a1cce823db37ed prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed .

	civic-kb:Status-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-f2de55ebc606800db7a1cce823db37ed	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-f2de55ebc606800db7a1cce823db37ed {
	civic-kb:nanoPub-f2de55ebc606800db7a1cce823db37ed prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-f2de55ebc606800db7a1cce823db37ed
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-df0c0ed01e02d0cc2a0cf620f1013910 {
	civic-kb:nanoPub-df0c0ed01e02d0cc2a0cf620f1013910
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-df0c0ed01e02d0cc2a0cf620f1013910 ;
		np:hasProvenance civic-kb:provenance-df0c0ed01e02d0cc2a0cf620f1013910 ;
		np:hasPublicationInfo civic-kb:pubInfo-df0c0ed01e02d0cc2a0cf620f1013910 .
}

civic-kb:assertion-df0c0ed01e02d0cc2a0cf620f1013910 {
	civic-kb:Drugs-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdf:type	chebi:41774 ;
		rdf:type	db:DB00675 ;
		rdfs:label	"Tamoxifen"^^xsd:string ;
		sio:hasValue	"Tamoxifen"^^xsd:string .

	civic-kb:Status-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"856"^^xsd:integer .

	civic-kb:Gene-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18021 ;
		rdf:type	uniprot:P24385 ;
		rdfs:label	"CCND1 Gene"^^xsd:string ;
		sio:hasValue	"CCND1"^^xsd:string .

	civic-kb:Variant-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18211 ;
		rdfs:label	"Overexpression"^^xsd:string ;
		sio:hasValue	"OVEREXPRESSION"^^xsd:string .

	civic-kb:Description-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"The authors performed a tissue microarray analysis of 167 postmenopausal breast cancers that had been randomized to treatment with or without tamoxifen.  ER +ve patients with high CCND1 tumor expression did not show any difference in survival between tamoxifen and no treatment."^^xsd:string .

	civic-kb:Disease-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdf:type	efo:1000649 ;
		rdf:type	doid:0060075 ;
		rdfs:label	"Estrogen-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-df0c0ed01e02d0cc2a0cf620f1013910 .

}

civic-kb:provenance-df0c0ed01e02d0cc2a0cf620f1013910 {
	civic-kb:assertion-df0c0ed01e02d0cc2a0cf620f1013910 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910 .

	civic-kb:Status-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-df0c0ed01e02d0cc2a0cf620f1013910	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-df0c0ed01e02d0cc2a0cf620f1013910 {
	civic-kb:nanoPub-df0c0ed01e02d0cc2a0cf620f1013910 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-df0c0ed01e02d0cc2a0cf620f1013910
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-a29fa6cc95bcd75adcf9b78fb7f8d065 {
	civic-kb:nanoPub-a29fa6cc95bcd75adcf9b78fb7f8d065
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		np:hasProvenance civic-kb:provenance-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		np:hasPublicationInfo civic-kb:pubInfo-a29fa6cc95bcd75adcf9b78fb7f8d065 .
}

civic-kb:assertion-a29fa6cc95bcd75adcf9b78fb7f8d065 {
	civic-kb:Drugs-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		sio:hasValue	"FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074, Dovitinib"^^xsd:string .

	civic-kb:Status-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"5828"^^xsd:integer .

	civic-kb:Gene-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C25859 ;
		rdf:type	uniprot:P22455 ;
		rdfs:label	"FGFR4 Gene"^^xsd:string ;
		sio:hasValue	"FGFR4"^^xsd:string .

	civic-kb:Variant-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18211 ;
		rdfs:label	"Overexpression"^^xsd:string ;
		sio:hasValue	"OVEREXPRESSION"^^xsd:string .

	civic-kb:Description-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"ERBB2-positive breast cancer cell lines including MDA-MB-361 and MDA-MB-453 were found to display outlier expression of FGFR4. Targeting FGFR4 in FGFR4 overexpressing ERBB2-positive breast cancer samples was found to confer independent as well as additive inhibitory effects upon their combined knockdown as well as pharmacological inhibition."^^xsd:string .

	civic-kb:Disease-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-a29fa6cc95bcd75adcf9b78fb7f8d065 .

}

civic-kb:provenance-a29fa6cc95bcd75adcf9b78fb7f8d065 {
	civic-kb:assertion-a29fa6cc95bcd75adcf9b78fb7f8d065 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065 .

	civic-kb:Status-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-a29fa6cc95bcd75adcf9b78fb7f8d065	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-a29fa6cc95bcd75adcf9b78fb7f8d065 {
	civic-kb:nanoPub-a29fa6cc95bcd75adcf9b78fb7f8d065 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-a29fa6cc95bcd75adcf9b78fb7f8d065
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-5b62f6c3c86b6d8accbe0e7a200009c9 {
	civic-kb:nanoPub-5b62f6c3c86b6d8accbe0e7a200009c9
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		np:hasProvenance civic-kb:provenance-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		np:hasPublicationInfo civic-kb:pubInfo-5b62f6c3c86b6d8accbe0e7a200009c9 .
}

civic-kb:assertion-5b62f6c3c86b6d8accbe0e7a200009c9 {
	civic-kb:Drugs-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdf:type	dron:00018224 ;
		rdf:type	db:DB01590 ;
		rdfs:label	"Everolimus"^^xsd:string ;
		sio:hasValue	"Everolimus"^^xsd:string .

	civic-kb:Status-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1296"^^xsd:integer .

	civic-kb:Gene-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C21220 ;
		rdf:type	uniprot:P42336 ;
		rdfs:label	"PIK3CA Gene"^^xsd:string ;
		sio:hasValue	"PIK3CA"^^xsd:string .

	civic-kb:Variant-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18093 ;
		rdfs:label	"Mutation"^^xsd:string ;
		sio:hasValue	"MUTATION"^^xsd:string .

	civic-kb:Description-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"Archival tumor samples from 549 patients from the BOLERO-1 and -3 trials were analyzed for alterations in the PI3K pathway using next-generation sequencing, immunohistochemistry (IHC) and Sanger sequencing. In the BOLERO trials, patients with HER2-overexpressing advanced breast cancer were treated with trastuzumab, chemotherapy and randomized to receive either everolimus or placebo. In the pooled analysis of both trials, patients with PI3K mutations had longer progression-free survival with everolimus compared to placebo (HR 0.67 95%CI 0.45 to 1.00, P=0.05) whereas patients with PI3K wild type status did not benefit significantly (HR 1.1, 95%CI 0.83 to 1.46, P=0.5). The same was found when PI3K mutations, PTEN loss and AKT E17K mutations were combinedly analyzed as hyperactive PI3K pathway. Patients with PI3K hyperactive pathway had a hazard ratio of 0.67 (95%CI 0.48 to 0.93, P=0.02) compared to HR 1.19 (95%CI 0.87 to 1.62, P=0.28) in patients with PI3K normal pathway. These trends were independently confirmed in both trials but only pooled results showed consistent statistical significance."^^xsd:string .

	civic-kb:Disease-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-5b62f6c3c86b6d8accbe0e7a200009c9 .

}

civic-kb:provenance-5b62f6c3c86b6d8accbe0e7a200009c9 {
	civic-kb:assertion-5b62f6c3c86b6d8accbe0e7a200009c9 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9 .

	civic-kb:Status-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-5b62f6c3c86b6d8accbe0e7a200009c9	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-5b62f6c3c86b6d8accbe0e7a200009c9 {
	civic-kb:nanoPub-5b62f6c3c86b6d8accbe0e7a200009c9 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-5b62f6c3c86b6d8accbe0e7a200009c9
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-99d4ceb568802d914016b31d3c9b5a16 {
	civic-kb:nanoPub-99d4ceb568802d914016b31d3c9b5a16
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-99d4ceb568802d914016b31d3c9b5a16 ;
		np:hasProvenance civic-kb:provenance-99d4ceb568802d914016b31d3c9b5a16 ;
		np:hasPublicationInfo civic-kb:pubInfo-99d4ceb568802d914016b31d3c9b5a16 .
}

civic-kb:assertion-99d4ceb568802d914016b31d3c9b5a16 {
	civic-kb:Drugs-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-99d4ceb568802d914016b31d3c9b5a16 ;
		rdf:type	dron:00013025 ;
		rdf:type	db:DB0007 ;
		rdfs:label	"Trastuzumab"^^xsd:string ;
		sio:hasValue	"Trastuzumab"^^xsd:string .

	civic-kb:Status-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1384"^^xsd:integer .

	civic-kb:Gene-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C21220 ;
		rdf:type	uniprot:P42336 ;
		rdfs:label	"PIK3CA Gene"^^xsd:string ;
		sio:hasValue	"PIK3CA"^^xsd:string .

	civic-kb:Variant-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18093 ;
		rdfs:label	"Mutation"^^xsd:string ;
		sio:hasValue	"MUTATION"^^xsd:string .

	civic-kb:Description-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"The HER2 overexpressing breast cancer cell line BT-474 transduced with mutant PIK3CA H1047R demonstrated essentially normal proliferation under trastuzumab, while control cells showed negligible proliferation with trastuzumab. Sequencing of 55 HER2 breast cancer samples revealed 25% PIK3CA mutation rate and Kaplan Meier curves showed decreased time to progression for mutant PIK3CA at borderline statistical significance (p=0.052). This was potentially explained by presence of PTEN loss in wild-type PIK3CA sample and combining PTEN loss with PIK3CA mutation resulted in significant differences in time to progression (p=0.007)."^^xsd:string .

	civic-kb:Disease-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-99d4ceb568802d914016b31d3c9b5a16 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-99d4ceb568802d914016b31d3c9b5a16 .

}

civic-kb:provenance-99d4ceb568802d914016b31d3c9b5a16 {
	civic-kb:assertion-99d4ceb568802d914016b31d3c9b5a16 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16 .

	civic-kb:Status-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-99d4ceb568802d914016b31d3c9b5a16	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-99d4ceb568802d914016b31d3c9b5a16 {
	civic-kb:nanoPub-99d4ceb568802d914016b31d3c9b5a16 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-99d4ceb568802d914016b31d3c9b5a16
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-c72ec571d8e85aae381d94e4eeb1c57d {
	civic-kb:nanoPub-c72ec571d8e85aae381d94e4eeb1c57d
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-c72ec571d8e85aae381d94e4eeb1c57d ;
		np:hasProvenance civic-kb:provenance-c72ec571d8e85aae381d94e4eeb1c57d ;
		np:hasPublicationInfo civic-kb:pubInfo-c72ec571d8e85aae381d94e4eeb1c57d .
}

civic-kb:assertion-c72ec571d8e85aae381d94e4eeb1c57d {
	civic-kb:Drugs-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-c72ec571d8e85aae381d94e4eeb1c57d ;
		sio:hasValue	"Carboplatin, Eribulin"^^xsd:string .

	civic-kb:Status-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"2969"^^xsd:integer .

	civic-kb:Gene-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C24284 ;
		rdf:type	uniprot:P24941 ;
		rdfs:label	"CDK2 Gene"^^xsd:string ;
		sio:hasValue	"CDK2"^^xsd:string .

	civic-kb:Variant-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Cytoplasmic Expression"^^xsd:string ;
		sio:hasValue	"CYTOPLASMIC EXPRESSION"^^xsd:string .

	civic-kb:Description-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In a Phase 2 trial, HRD score, HR deficiency status, and cytoplasmic CDK2 predicted pathologic complete remission to neoadjuvant therapy with carboplatin and eribulin in early stage TNBC patients."^^xsd:string .

	civic-kb:Disease-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdf:type	efo:0005537 ;
		rdf:type	ncit:C71428 ;
		rdf:type	doid:60081 ;
		rdfs:label	"Triple-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Triple-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-c72ec571d8e85aae381d94e4eeb1c57d .

}

civic-kb:provenance-c72ec571d8e85aae381d94e4eeb1c57d {
	civic-kb:assertion-c72ec571d8e85aae381d94e4eeb1c57d prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d .

	civic-kb:Status-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-c72ec571d8e85aae381d94e4eeb1c57d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-c72ec571d8e85aae381d94e4eeb1c57d {
	civic-kb:nanoPub-c72ec571d8e85aae381d94e4eeb1c57d prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-c72ec571d8e85aae381d94e4eeb1c57d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-a37d3f28925ba968a59dd38d62622a9e {
	civic-kb:nanoPub-a37d3f28925ba968a59dd38d62622a9e
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-a37d3f28925ba968a59dd38d62622a9e ;
		np:hasProvenance civic-kb:provenance-a37d3f28925ba968a59dd38d62622a9e ;
		np:hasPublicationInfo civic-kb:pubInfo-a37d3f28925ba968a59dd38d62622a9e .
}

civic-kb:assertion-a37d3f28925ba968a59dd38d62622a9e {
	civic-kb:Drugs-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label	"AKT3 Inhibitor"^^xsd:string ;
		sio:hasValue	"AKT3 Inhibitor"^^xsd:string .

	civic-kb:Status-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1923"^^xsd:integer .

	civic-kb:Gene-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C20937 ;
		rdf:type	uniprot:Q9Y243 ;
		rdfs:label	"AKT3 Gene"^^xsd:string ;
		sio:hasValue	"AKT3"^^xsd:string .

	civic-kb:Variant-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18211 ;
		rdfs:label	"Overexpression"^^xsd:string ;
		sio:hasValue	"OVEREXPRESSION"^^xsd:string .

	civic-kb:Description-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"AKT3 was found to be preferentially required for the proliferation and tumor growth of TNBC. It was found to be upregulated in a set of TNBC cell lines compared to other breast cancer types. Depletion of AKT3 in TNBC sensitizes cells to the pan-Akt inhibitor GSK690693. It was found that depletion of Akt3 potentially inhibits the growth of TNBC cell lines in three-dimensional (3D) spheroid cultures and in mouse xenograft models, which imply that therapeutic targeting of AKT3 may provide a new treatment option for TNBCs."^^xsd:string .

	civic-kb:Disease-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-a37d3f28925ba968a59dd38d62622a9e ;
		rdf:type	efo:0005537 ;
		rdf:type	ncit:C71428 ;
		rdf:type	doid:60081 ;
		rdfs:label	"Triple-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Triple-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"E"^^xsd:string .

	civic-kb:Evidence_Type-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-a37d3f28925ba968a59dd38d62622a9e .

}

civic-kb:provenance-a37d3f28925ba968a59dd38d62622a9e {
	civic-kb:assertion-a37d3f28925ba968a59dd38d62622a9e prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e .

	civic-kb:Status-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-a37d3f28925ba968a59dd38d62622a9e	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-a37d3f28925ba968a59dd38d62622a9e {
	civic-kb:nanoPub-a37d3f28925ba968a59dd38d62622a9e prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-a37d3f28925ba968a59dd38d62622a9e
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-4f0514866dd37f223619edbe386aa3ff {
	civic-kb:nanoPub-4f0514866dd37f223619edbe386aa3ff
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-4f0514866dd37f223619edbe386aa3ff ;
		np:hasProvenance civic-kb:provenance-4f0514866dd37f223619edbe386aa3ff ;
		np:hasPublicationInfo civic-kb:pubInfo-4f0514866dd37f223619edbe386aa3ff .
}

civic-kb:assertion-4f0514866dd37f223619edbe386aa3ff {
	civic-kb:Drugs-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-4f0514866dd37f223619edbe386aa3ff ;
		rdf:type	dron:00730818 ;
		rdf:type	db:DB05773 ;
		rdfs:label	"Ado-trastuzumab Emtansine"^^xsd:string ;
		sio:hasValue	"Ado-trastuzumab Emtansine"^^xsd:string .

	civic-kb:Status-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"4840"^^xsd:integer .

	civic-kb:Gene-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18211 ;
		rdfs:label	"Overexpression"^^xsd:string ;
		sio:hasValue	"OVEREXPRESSION"^^xsd:string .

	civic-kb:Description-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"Trastuzumab emtansine has its indication for patients with HER2-positive metastatic breast cancer after therapy with Trastuzumab and Taxane, approval based on PFS and preliminary OS data. EMILIA was a randomised open-label, phase III study for patients with HER2-positive, unresectable, locally advanced, or metastatic breast cancer previously treated with Trastuzumab and a Taxane, randomized 1:1 to Trastuzumab-emtansine or Capecitabine plus Lapatinib. 991 patients were enrolled. Median OS was 29.9m vs. 25.9m. Fewer grade 3 or worse AE occurred with trastuzumab emtansine than with capecitabine plus lapatinib control treatment."^^xsd:string .

	civic-kb:Disease-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-4f0514866dd37f223619edbe386aa3ff ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-4f0514866dd37f223619edbe386aa3ff .

}

civic-kb:provenance-4f0514866dd37f223619edbe386aa3ff {
	civic-kb:assertion-4f0514866dd37f223619edbe386aa3ff prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff .

	civic-kb:Status-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-4f0514866dd37f223619edbe386aa3ff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-4f0514866dd37f223619edbe386aa3ff {
	civic-kb:nanoPub-4f0514866dd37f223619edbe386aa3ff prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-4f0514866dd37f223619edbe386aa3ff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-19de61082ce0e87490ed5d802e34f728 {
	civic-kb:nanoPub-19de61082ce0e87490ed5d802e34f728
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-19de61082ce0e87490ed5d802e34f728 ;
		np:hasProvenance civic-kb:provenance-19de61082ce0e87490ed5d802e34f728 ;
		np:hasPublicationInfo civic-kb:pubInfo-19de61082ce0e87490ed5d802e34f728 .
}

civic-kb:assertion-19de61082ce0e87490ed5d802e34f728 {
	civic-kb:Drugs-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-19de61082ce0e87490ed5d802e34f728 ;
		rdf:type	db:DB08901 ;
		rdfs:label	"Ponatinib"^^xsd:string ;
		sio:hasValue	"Ponatinib"^^xsd:string .

	civic-kb:Status-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1767"^^xsd:integer .

	civic-kb:Gene-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C19929 ;
		rdf:type	uniprot:P11362 ;
		rdfs:label	"FGFR1 Gene"^^xsd:string ;
		sio:hasValue	"FGFR1"^^xsd:string .

	civic-kb:Variant-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In MDA-MB-134 cells (ER-positive breast cancer cells with amplified FGFR1) ponatinib potently inhibited cell growth with a GI50 value of 23 nmol/L and inhibited FGFR1 phosphorylation with an IC50 value of 7 nmol/L."^^xsd:string .

	civic-kb:Disease-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-19de61082ce0e87490ed5d802e34f728 ;
		rdf:type	efo:1000649 ;
		rdf:type	doid:0060075 ;
		rdfs:label	"Estrogen-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-19de61082ce0e87490ed5d802e34f728	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-19de61082ce0e87490ed5d802e34f728 .

}

civic-kb:provenance-19de61082ce0e87490ed5d802e34f728 {
	civic-kb:assertion-19de61082ce0e87490ed5d802e34f728 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-19de61082ce0e87490ed5d802e34f728 .

	civic-kb:Status-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-19de61082ce0e87490ed5d802e34f728	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-19de61082ce0e87490ed5d802e34f728 {
	civic-kb:nanoPub-19de61082ce0e87490ed5d802e34f728 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-19de61082ce0e87490ed5d802e34f728
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-e76c5cb591ee4be17df063c08196778d {
	civic-kb:nanoPub-e76c5cb591ee4be17df063c08196778d
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-e76c5cb591ee4be17df063c08196778d ;
		np:hasProvenance civic-kb:provenance-e76c5cb591ee4be17df063c08196778d ;
		np:hasPublicationInfo civic-kb:pubInfo-e76c5cb591ee4be17df063c08196778d .
}

civic-kb:assertion-e76c5cb591ee4be17df063c08196778d {
	civic-kb:Drugs-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e76c5cb591ee4be17df063c08196778d ;
		rdf:type	db:DB09073 ;
		rdfs:label	"Palbociclib"^^xsd:string ;
		sio:hasValue	"Palbociclib (PD0332991)"^^xsd:string .

	civic-kb:Status-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1630"^^xsd:integer .

	civic-kb:Gene-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17360 ;
		rdf:type	uniprot:P06400 ;
		rdfs:label	"RB1 Gene"^^xsd:string ;
		sio:hasValue	"RB1"^^xsd:string .

	civic-kb:Variant-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"M695FS*26"^^xsd:string ;
		sio:hasValue	"M695FS*26"^^xsd:string .

	civic-kb:Description-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"Preclinical study in breast cancer cell lines treated with CDK4/6 inhibitor palbociclib. Palbociclib-resistant xenografts from one cell line (PDX244) were developed in-vivo. In resistant xenografts, western blot analysis showed a decrease of pRb protein levels in 4 of 7 CDK4/6-acquired resistant tumors and a sustained expression of the E2F target cyclin E2, in contrast to CDK4/6 inhibitor-sensitive PDX244. Genomic characterization of PDX244LR1 showed the acquisition of an RB1 frameshift mutation (RB1 p.M695fs*26)."^^xsd:string .

	civic-kb:Disease-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e76c5cb591ee4be17df063c08196778d ;
		rdf:type	efo:1000649 ;
		rdf:type	doid:0060075 ;
		rdfs:label	"Estrogen-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-e76c5cb591ee4be17df063c08196778d ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-e76c5cb591ee4be17df063c08196778d	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-e76c5cb591ee4be17df063c08196778d .

}

civic-kb:provenance-e76c5cb591ee4be17df063c08196778d {
	civic-kb:assertion-e76c5cb591ee4be17df063c08196778d prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-e76c5cb591ee4be17df063c08196778d .

	civic-kb:Status-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-e76c5cb591ee4be17df063c08196778d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-e76c5cb591ee4be17df063c08196778d {
	civic-kb:nanoPub-e76c5cb591ee4be17df063c08196778d prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-e76c5cb591ee4be17df063c08196778d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-790acd838ebb03d816ee9e9fb2e91726 {
	civic-kb:nanoPub-790acd838ebb03d816ee9e9fb2e91726
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-790acd838ebb03d816ee9e9fb2e91726 ;
		np:hasProvenance civic-kb:provenance-790acd838ebb03d816ee9e9fb2e91726 ;
		np:hasPublicationInfo civic-kb:pubInfo-790acd838ebb03d816ee9e9fb2e91726 .
}

civic-kb:assertion-790acd838ebb03d816ee9e9fb2e91726 {
	civic-kb:Drugs-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-790acd838ebb03d816ee9e9fb2e91726 ;
		rdf:type	ncit:C1740 ;
		rdf:type	chebi:50790 ;
		rdfs:label	"Aromatase Inhibitor"^^xsd:string ;
		sio:hasValue	"Aromatase Inhibitor"^^xsd:string .

	civic-kb:Status-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1727"^^xsd:integer .

	civic-kb:Gene-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C38349 ;
		rdf:type	uniprot:P03372 ;
		rdfs:label	"ESR1 Gene"^^xsd:string ;
		sio:hasValue	"ESR1"^^xsd:string .

	civic-kb:Variant-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"S463P"^^xsd:string ;
		sio:hasValue	"S463P"^^xsd:string .

	civic-kb:Description-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string .

	civic-kb:Disease-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-790acd838ebb03d816ee9e9fb2e91726 ;
		rdf:type	efo:1000649 ;
		rdf:type	doid:0060075 ;
		rdfs:label	"Estrogen-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-790acd838ebb03d816ee9e9fb2e91726 .

}

civic-kb:provenance-790acd838ebb03d816ee9e9fb2e91726 {
	civic-kb:assertion-790acd838ebb03d816ee9e9fb2e91726 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726 .

	civic-kb:Status-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-790acd838ebb03d816ee9e9fb2e91726	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-790acd838ebb03d816ee9e9fb2e91726 {
	civic-kb:nanoPub-790acd838ebb03d816ee9e9fb2e91726 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-790acd838ebb03d816ee9e9fb2e91726
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 {
	civic-kb:nanoPub-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		np:hasProvenance civic-kb:provenance-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		np:hasPublicationInfo civic-kb:pubInfo-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 .
}

civic-kb:assertion-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 {
	civic-kb:Drugs-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdf:type	chebi:50914 ;
		rdfs:label	"Tgx 221"^^xsd:string ;
		sio:hasValue	"Tgx 221"^^xsd:string .

	civic-kb:Status-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1382"^^xsd:integer .

	civic-kb:Gene-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"Treatment of cells obtained from MMTV-NeuT mouse mammary tumors with the p110beta selective inhibitor TGX-221 showed significant but minimal reductions in lipid kinase activity and negligible reductions in phospho Akt levels. In simmilar cells subjected to p110alpha isoform knockout, TGX-221 treatment fully blocked Akt activation, indicating that TGX-221 was fully inhibiting the p110beta isoform. Athymic mice recieved MMTV-NeuT tumor cell transplants and were treated with TGX-221, which resulted in significant but minimal reduction in tumor growth compared to controls."^^xsd:string .

	civic-kb:Disease-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Does Not Support"^^xsd:string .

	civic-kb:Clinical_Significance-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 .

}

civic-kb:provenance-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 {
	civic-kb:assertion-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 .

	civic-kb:Status-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-e2aba4b28f3cc9fbfbe9ddf07f3b95e0	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 {
	civic-kb:nanoPub-e2aba4b28f3cc9fbfbe9ddf07f3b95e0 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-e2aba4b28f3cc9fbfbe9ddf07f3b95e0
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-a90daca011c2f1078e64357e8e8c62de {
	civic-kb:nanoPub-a90daca011c2f1078e64357e8e8c62de
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-a90daca011c2f1078e64357e8e8c62de ;
		np:hasProvenance civic-kb:provenance-a90daca011c2f1078e64357e8e8c62de ;
		np:hasPublicationInfo civic-kb:pubInfo-a90daca011c2f1078e64357e8e8c62de .
}

civic-kb:assertion-a90daca011c2f1078e64357e8e8c62de {
	civic-kb:Drugs-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-a90daca011c2f1078e64357e8e8c62de ;
		rdf:type	dron:00730818 ;
		rdf:type	db:DB05773 ;
		rdfs:label	"Trastuzumab Emtansine"^^xsd:string ;
		sio:hasValue	"Trastuzumab Emtansine"^^xsd:string .

	civic-kb:Status-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1432"^^xsd:integer .

	civic-kb:Gene-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In a randomized phase II study, first line treatment of HER2-positive metastatic breast cancer with trastuzumab emtansine (T-DM1) resulted in improved progression free survival and fewer serious adverse effects when compared to treatment with combination trastuzumab plus docetaxel (HT) (median follow up 14 months, median PFS with T-DM1 14.2 vs 9.2 with HT)."^^xsd:string .

	civic-kb:Disease-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-a90daca011c2f1078e64357e8e8c62de ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-a90daca011c2f1078e64357e8e8c62de .

}

civic-kb:provenance-a90daca011c2f1078e64357e8e8c62de {
	civic-kb:assertion-a90daca011c2f1078e64357e8e8c62de prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de .

	civic-kb:Status-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-a90daca011c2f1078e64357e8e8c62de	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-a90daca011c2f1078e64357e8e8c62de {
	civic-kb:nanoPub-a90daca011c2f1078e64357e8e8c62de prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-a90daca011c2f1078e64357e8e8c62de
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-6c91548cf187d736ab82a114374f7055 {
	civic-kb:nanoPub-6c91548cf187d736ab82a114374f7055
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-6c91548cf187d736ab82a114374f7055 ;
		np:hasProvenance civic-kb:provenance-6c91548cf187d736ab82a114374f7055 ;
		np:hasPublicationInfo civic-kb:pubInfo-6c91548cf187d736ab82a114374f7055 .
}

civic-kb:assertion-6c91548cf187d736ab82a114374f7055 {
	civic-kb:Drugs-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-6c91548cf187d736ab82a114374f7055 ;
		sio:hasValue	"Afatinib, Lapatinib, Trastuzumab"^^xsd:string .

	civic-kb:Status-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"887"^^xsd:integer .

	civic-kb:Gene-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In this phase 2 trial, treatment-naive, ERBB2-positive (by IHC) breast cancer patients with stage IIIA, B, C or inflammatory disease were randomized 1:1:1 to afatinib (n = 10), lapatinib (n = 8), or trastuzumab (n = 11). The primary end point was objective response rate. Objective response was seen in 8 afatinib-, 6 lapatinib-, and 4 trastuzumab-treated patients. Afatinib demonstrated clinical activity that compared favorably to trastuzumab and lapatinib for neoadjuvant treatment of HER2-positive breast cancer."^^xsd:string .

	civic-kb:Disease-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-6c91548cf187d736ab82a114374f7055 ;
		rdf:type	efo:0000305 ;
		rdf:type	ncit:C4872 ;
		rdf:type	doid:1612 ;
		rdfs:label	"Breast Cancer"^^xsd:string ;
		sio:hasValue	"Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-6c91548cf187d736ab82a114374f7055 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-6c91548cf187d736ab82a114374f7055	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-6c91548cf187d736ab82a114374f7055 .

}

civic-kb:provenance-6c91548cf187d736ab82a114374f7055 {
	civic-kb:assertion-6c91548cf187d736ab82a114374f7055 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-6c91548cf187d736ab82a114374f7055 .

	civic-kb:Status-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-6c91548cf187d736ab82a114374f7055	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-6c91548cf187d736ab82a114374f7055 {
	civic-kb:nanoPub-6c91548cf187d736ab82a114374f7055 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-6c91548cf187d736ab82a114374f7055
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-0e8e5d59589de7d3825e38904f101449 {
	civic-kb:nanoPub-0e8e5d59589de7d3825e38904f101449
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-0e8e5d59589de7d3825e38904f101449 ;
		np:hasProvenance civic-kb:provenance-0e8e5d59589de7d3825e38904f101449 ;
		np:hasPublicationInfo civic-kb:pubInfo-0e8e5d59589de7d3825e38904f101449 .
}

civic-kb:assertion-0e8e5d59589de7d3825e38904f101449 {
	civic-kb:Drugs-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-0e8e5d59589de7d3825e38904f101449 ;
		sio:hasValue	"Trastuzumab, Palbociclib (PD0332991)"^^xsd:string .

	civic-kb:Status-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1561"^^xsd:integer .

	civic-kb:Gene-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In a panel of 47 breast cancer cell lines, HER2 overexpressing cells were among those more sensitive to CDK4/6 inhibitor Palbociclib (PD0332991). In the trastuzumab sensitive cell line Bt474, palbociclib synergized with trastuzumab in growth inhibition, while in 2 trastuzumab resistant cell lines, addition of trastuzumab to palbociclib treatment resulted in increased growth inhibition over palbociclib alone."^^xsd:string .

	civic-kb:Disease-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-0e8e5d59589de7d3825e38904f101449 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-0e8e5d59589de7d3825e38904f101449	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-0e8e5d59589de7d3825e38904f101449 .

}

civic-kb:provenance-0e8e5d59589de7d3825e38904f101449 {
	civic-kb:assertion-0e8e5d59589de7d3825e38904f101449 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-0e8e5d59589de7d3825e38904f101449 .

	civic-kb:Status-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-0e8e5d59589de7d3825e38904f101449	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-0e8e5d59589de7d3825e38904f101449 {
	civic-kb:nanoPub-0e8e5d59589de7d3825e38904f101449 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-0e8e5d59589de7d3825e38904f101449
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-847d5e9ff7867c88cf3dfdb483b7ffda {
	civic-kb:nanoPub-847d5e9ff7867c88cf3dfdb483b7ffda
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-847d5e9ff7867c88cf3dfdb483b7ffda ;
		np:hasProvenance civic-kb:provenance-847d5e9ff7867c88cf3dfdb483b7ffda ;
		np:hasPublicationInfo civic-kb:pubInfo-847d5e9ff7867c88cf3dfdb483b7ffda .
}

civic-kb:assertion-847d5e9ff7867c88cf3dfdb483b7ffda {
	civic-kb:Drugs-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdf:type	dron:00730818 ;
		rdf:type	db:DB05773 ;
		rdfs:label	"Trastuzumab Emtansine"^^xsd:string ;
		sio:hasValue	"Trastuzumab Emtansine"^^xsd:string .

	civic-kb:Status-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1764"^^xsd:integer .

	civic-kb:Gene-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In the single arm Phase II study (TDM4258g) breast cancer patients who had progressed on previous anti-HER2 therapy were given transtuzumab emtansine (T-DM1), a HER2 monoclonal antibody and antimicrotubule drug conjugate. 95 trial participants with archival primary tumor were reassessed for HER2 status (positivity defined by FISH or IHC 3+), and 74 patients were confirmed for HER2 positivity and 21 were normal. Overall response rate was 33.8% (95% CI, 23.2% to 44.9%) in patients with confirmed HER2-positive tumors and 4.8% (95% CI, 1.0% to 21.8%) in HER2 normal patients. Median PFS was 8.2 months (95% CI, 4.4 months to not estimable) in patients with confirmed HER2-positive tumors and 2.6 months (95% CI, 1.4 to 3.9 months) in HER2 normal patients."^^xsd:string .

	civic-kb:Disease-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-847d5e9ff7867c88cf3dfdb483b7ffda .

}

civic-kb:provenance-847d5e9ff7867c88cf3dfdb483b7ffda {
	civic-kb:assertion-847d5e9ff7867c88cf3dfdb483b7ffda prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda .

	civic-kb:Status-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-847d5e9ff7867c88cf3dfdb483b7ffda	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-847d5e9ff7867c88cf3dfdb483b7ffda {
	civic-kb:nanoPub-847d5e9ff7867c88cf3dfdb483b7ffda prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-847d5e9ff7867c88cf3dfdb483b7ffda
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-f9337025873e0cc330ed5cbcb9906474 {
	civic-kb:nanoPub-f9337025873e0cc330ed5cbcb9906474
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-f9337025873e0cc330ed5cbcb9906474 ;
		np:hasProvenance civic-kb:provenance-f9337025873e0cc330ed5cbcb9906474 ;
		np:hasPublicationInfo civic-kb:pubInfo-f9337025873e0cc330ed5cbcb9906474 .
}

civic-kb:assertion-f9337025873e0cc330ed5cbcb9906474 {
	civic-kb:Drugs-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-f9337025873e0cc330ed5cbcb9906474 ;
		rdf:type	dron:00013025 ;
		rdf:type	db:DB0007 ;
		rdfs:label	"Trastuzumab"^^xsd:string ;
		sio:hasValue	"Trastuzumab"^^xsd:string .

	civic-kb:Status-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1122"^^xsd:integer .

	civic-kb:Gene-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"HERA was a Phase III trial assessing application of trastuzumab in an extended adjuvant setting.  Patients were HER2 positive with completely excised invasive BC, node positive or negative, and having undergone prior adjuvant or neo-adjuvant chemotherapy.  In the 3 arm study patients were given trastuzumab courses of 1 year, 2 years, or untreated.  At the first planned interim analysis, trastuzumab treatment for one year was compared with observation alone.  A significant difference in disease-free survival was seen with 220 DFS events out of 1693 in the observation arm versus 127 DFS events out of 1694 in the 1 year trastuzumab arm.  1 year adjuvant trastuzumab is currently the standard of care."^^xsd:string .

	civic-kb:Disease-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-f9337025873e0cc330ed5cbcb9906474 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"A"^^xsd:string .

	civic-kb:Evidence_Type-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-f9337025873e0cc330ed5cbcb9906474 .

}

civic-kb:provenance-f9337025873e0cc330ed5cbcb9906474 {
	civic-kb:assertion-f9337025873e0cc330ed5cbcb9906474 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474 .

	civic-kb:Status-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-f9337025873e0cc330ed5cbcb9906474	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-f9337025873e0cc330ed5cbcb9906474 {
	civic-kb:nanoPub-f9337025873e0cc330ed5cbcb9906474 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-f9337025873e0cc330ed5cbcb9906474
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-7667155189ffb3b53dfe1ee73e590998 {
	civic-kb:nanoPub-7667155189ffb3b53dfe1ee73e590998
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-7667155189ffb3b53dfe1ee73e590998 ;
		np:hasProvenance civic-kb:provenance-7667155189ffb3b53dfe1ee73e590998 ;
		np:hasPublicationInfo civic-kb:pubInfo-7667155189ffb3b53dfe1ee73e590998 .
}

civic-kb:assertion-7667155189ffb3b53dfe1ee73e590998 {
	civic-kb:Drugs-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-7667155189ffb3b53dfe1ee73e590998 ;
		rdf:type	dron:00013025 ;
		rdf:type	db:DB0007 ;
		rdfs:label	"Trastuzumab"^^xsd:string ;
		sio:hasValue	"Trastuzumab"^^xsd:string .

	civic-kb:Status-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"528"^^xsd:integer .

	civic-kb:Gene-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"A randomized clinical trial of 469 patients with previously untreated, HER2-positive, metastatic breast cancer demonstrated improved time to disease progression, objective response rate, and duration of response for patients who received trastuzumab in addition to chemotherapy compared to chemotherapy alone."^^xsd:string .

	civic-kb:Disease-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-7667155189ffb3b53dfe1ee73e590998 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"5"^^xsd:integer .

	civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-7667155189ffb3b53dfe1ee73e590998 .

}

civic-kb:provenance-7667155189ffb3b53dfe1ee73e590998 {
	civic-kb:assertion-7667155189ffb3b53dfe1ee73e590998 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998 .

	civic-kb:Status-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-7667155189ffb3b53dfe1ee73e590998	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-7667155189ffb3b53dfe1ee73e590998 {
	civic-kb:nanoPub-7667155189ffb3b53dfe1ee73e590998 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-7667155189ffb3b53dfe1ee73e590998
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-40344abcdd6cdd8615de4a954b2eb716 {
	civic-kb:nanoPub-40344abcdd6cdd8615de4a954b2eb716
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-40344abcdd6cdd8615de4a954b2eb716 ;
		np:hasProvenance civic-kb:provenance-40344abcdd6cdd8615de4a954b2eb716 ;
		np:hasPublicationInfo civic-kb:pubInfo-40344abcdd6cdd8615de4a954b2eb716 .
}

civic-kb:assertion-40344abcdd6cdd8615de4a954b2eb716 {
	civic-kb:Drugs-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-40344abcdd6cdd8615de4a954b2eb716 ;
		rdf:type	dron:00013025 ;
		rdf:type	db:DB0007 ;
		rdfs:label	"Trastuzumab"^^xsd:string ;
		sio:hasValue	"Trastuzumab"^^xsd:string .

	civic-kb:Status-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"529"^^xsd:integer .

	civic-kb:Gene-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"A randomized clinical trial of 186 patients with previously untreated, HER2-positive, metastatic breast cancer demonstrated improved overall survival, response rate, response duration, time to progression, and time to treatment failure for patients who received trastuzumab in addition to chemotherapy (docetaxel) compared to chemotherapy alone."^^xsd:string .

	civic-kb:Disease-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-40344abcdd6cdd8615de4a954b2eb716 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"5"^^xsd:integer .

	civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-40344abcdd6cdd8615de4a954b2eb716 .

}

civic-kb:provenance-40344abcdd6cdd8615de4a954b2eb716 {
	civic-kb:assertion-40344abcdd6cdd8615de4a954b2eb716 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716 .

	civic-kb:Status-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-40344abcdd6cdd8615de4a954b2eb716	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-40344abcdd6cdd8615de4a954b2eb716 {
	civic-kb:nanoPub-40344abcdd6cdd8615de4a954b2eb716 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-40344abcdd6cdd8615de4a954b2eb716
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-00506af562570bbb19597991ed8590fa {
	civic-kb:nanoPub-00506af562570bbb19597991ed8590fa
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-00506af562570bbb19597991ed8590fa ;
		np:hasProvenance civic-kb:provenance-00506af562570bbb19597991ed8590fa ;
		np:hasPublicationInfo civic-kb:pubInfo-00506af562570bbb19597991ed8590fa .
}

civic-kb:assertion-00506af562570bbb19597991ed8590fa {
	civic-kb:Drugs-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-00506af562570bbb19597991ed8590fa ;
		rdf:type	chebi:49960 ;
		rdf:type	db:DB05294 ;
		rdf:type	db:DB08764 ;
		rdfs:label	"Vandetanib"^^xsd:string ;
		sio:hasValue	"Vandetanib"^^xsd:string .

	civic-kb:Status-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"2992"^^xsd:integer .

	civic-kb:Gene-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18539 ;
		rdf:type	uniprot:P07949 ;
		rdfs:label	"RET Gene"^^xsd:string ;
		sio:hasValue	"RET"^^xsd:string .

	civic-kb:Variant-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18211 ;
		rdfs:label	"Overexpression"^^xsd:string ;
		sio:hasValue	"OVEREXPRESSION"^^xsd:string .

	civic-kb:Description-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"The activity of Vandetanib was tested in vivo in three PDX models of TNBC and one model of HER2+ BC with different expression levels of RET and EGFR. Vandetanib induced tumor regression in PDX models with high expression of RET or EGFR. The effect was associated with inhibition of RET/EGFR phosphorylation and MAP kinase pathway and increased necrosis. In a PDX model with no expression of RET nor EGFR, Vandetanib slowed tumor growth without inducing tumor regression. In addition, treatment by Vandetanib decreased expression of murine Vegf receptors and the endothelial marker Cd31 in the four PDX models tested, suggesting inhibition of tumor vascularization."^^xsd:string .

	civic-kb:Disease-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-00506af562570bbb19597991ed8590fa ;
		rdf:type	efo:1000650 ;
		rdf:type	doid:0060076 ;
		rdfs:label	"Estrogen-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-00506af562570bbb19597991ed8590fa ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-00506af562570bbb19597991ed8590fa	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-00506af562570bbb19597991ed8590fa .

}

civic-kb:provenance-00506af562570bbb19597991ed8590fa {
	civic-kb:assertion-00506af562570bbb19597991ed8590fa prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-00506af562570bbb19597991ed8590fa .

	civic-kb:Status-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-00506af562570bbb19597991ed8590fa	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-00506af562570bbb19597991ed8590fa {
	civic-kb:nanoPub-00506af562570bbb19597991ed8590fa prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-00506af562570bbb19597991ed8590fa
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-62c33c14d1830da6a886e9d381dd5cff {
	civic-kb:nanoPub-62c33c14d1830da6a886e9d381dd5cff
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-62c33c14d1830da6a886e9d381dd5cff ;
		np:hasProvenance civic-kb:provenance-62c33c14d1830da6a886e9d381dd5cff ;
		np:hasPublicationInfo civic-kb:pubInfo-62c33c14d1830da6a886e9d381dd5cff .
}

civic-kb:assertion-62c33c14d1830da6a886e9d381dd5cff {
	civic-kb:Drugs-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-62c33c14d1830da6a886e9d381dd5cff ;
		sio:hasValue	"Fulvestrant, Palbociclib (PD0332991)"^^xsd:string .

	civic-kb:Status-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1527"^^xsd:integer .

	civic-kb:Gene-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C97384 ;
		rdf:type	uniprot:Q00534 ;
		rdfs:label	"CDK6 Gene"^^xsd:string ;
		sio:hasValue	"CDK6"^^xsd:string .

	civic-kb:Variant-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18211 ;
		rdfs:label	"Overexpression"^^xsd:string ;
		sio:hasValue	"OVEREXPRESSION"^^xsd:string .

	civic-kb:Description-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"Four fulvestrant (estrogen receptor degrader) resistant cell lines were derived from parent fulvestrant sensitive ER+ MCF-7/SO.5 breast cancer cell line. Derivative cell lines showed some sensitivity to CDK4/6 inhibitor palbociclib, and increased growth inhibition when treated with fulvestrant and palbociclib together."^^xsd:string .

	civic-kb:Disease-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-62c33c14d1830da6a886e9d381dd5cff ;
		rdf:type	efo:1000649 ;
		rdf:type	doid:0060075 ;
		rdfs:label	"Estrogen-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-62c33c14d1830da6a886e9d381dd5cff .

}

civic-kb:provenance-62c33c14d1830da6a886e9d381dd5cff {
	civic-kb:assertion-62c33c14d1830da6a886e9d381dd5cff prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff .

	civic-kb:Status-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-62c33c14d1830da6a886e9d381dd5cff	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-62c33c14d1830da6a886e9d381dd5cff {
	civic-kb:nanoPub-62c33c14d1830da6a886e9d381dd5cff prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-62c33c14d1830da6a886e9d381dd5cff
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-68b01e3dc5951134a1998e6a32da18d7 {
	civic-kb:nanoPub-68b01e3dc5951134a1998e6a32da18d7
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-68b01e3dc5951134a1998e6a32da18d7 ;
		np:hasProvenance civic-kb:provenance-68b01e3dc5951134a1998e6a32da18d7 ;
		np:hasPublicationInfo civic-kb:pubInfo-68b01e3dc5951134a1998e6a32da18d7 .
}

civic-kb:assertion-68b01e3dc5951134a1998e6a32da18d7 {
	civic-kb:Drugs-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-68b01e3dc5951134a1998e6a32da18d7 ;
		rdf:type	dron:00018972 ;
		rdf:type	db:DB00947 ;
		rdfs:label	"Fulvestrant"^^xsd:string ;
		sio:hasValue	"Fulvestrant"^^xsd:string .

	civic-kb:Status-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1526"^^xsd:integer .

	civic-kb:Gene-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C97384 ;
		rdf:type	uniprot:Q00534 ;
		rdfs:label	"CDK6 Gene"^^xsd:string ;
		sio:hasValue	"CDK6"^^xsd:string .

	civic-kb:Variant-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18211 ;
		rdfs:label	"Overexpression"^^xsd:string ;
		sio:hasValue	"OVEREXPRESSION"^^xsd:string .

	civic-kb:Description-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In two cohorts (n=45 and n=46) of ER+ breast cancer patients who had received fulvestrant, CDK6 overexpression correlated with shorter median time to progression in both cohorts (2.5 vs. 8.2 months and 3.4 vs. 8.9 months for CDK6 overexpression vs. normal expression). CDK6 expression did not correlate with other lines of treatment (N=68, tamoxifen or endocrine therapy). Four fulvestrant-resistant cell lines were derived from estrogen responsive and fulvestrant sensitive parental breast cancer cell line MCF-7/SO.5. Gene expression profiling showed upregulation of CDK6 in the fulvestrant resistant derivatives. Knockdown of CDK6 in these derivative cells resulted in fulvestrant sensitivity."^^xsd:string .

	civic-kb:Disease-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-68b01e3dc5951134a1998e6a32da18d7 ;
		rdf:type	efo:1000649 ;
		rdf:type	doid:0060075 ;
		rdfs:label	"Estrogen-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-68b01e3dc5951134a1998e6a32da18d7 .

}

civic-kb:provenance-68b01e3dc5951134a1998e6a32da18d7 {
	civic-kb:assertion-68b01e3dc5951134a1998e6a32da18d7 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7 .

	civic-kb:Status-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-68b01e3dc5951134a1998e6a32da18d7	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-68b01e3dc5951134a1998e6a32da18d7 {
	civic-kb:nanoPub-68b01e3dc5951134a1998e6a32da18d7 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-68b01e3dc5951134a1998e6a32da18d7
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-d409da7f061ef751522b2ba85ae1e5c1 {
	civic-kb:nanoPub-d409da7f061ef751522b2ba85ae1e5c1
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-d409da7f061ef751522b2ba85ae1e5c1 ;
		np:hasProvenance civic-kb:provenance-d409da7f061ef751522b2ba85ae1e5c1 ;
		np:hasPublicationInfo civic-kb:pubInfo-d409da7f061ef751522b2ba85ae1e5c1 .
}

civic-kb:assertion-d409da7f061ef751522b2ba85ae1e5c1 {
	civic-kb:Drugs-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdf:type	dron:00018921 ;
		rdf:type	db:DB01259 ;
		rdfs:label	"Lapatinib"^^xsd:string ;
		sio:hasValue	"Lapatinib"^^xsd:string .

	civic-kb:Status-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"3052"^^xsd:integer .

	civic-kb:Gene-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Non-amplification"^^xsd:string ;
		sio:hasValue	"NON-AMPLIFICATION"^^xsd:string .

	civic-kb:Description-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string .

	civic-kb:Disease-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdf:type	doid:0060080 ;
		rdfs:label	"Her2-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-d409da7f061ef751522b2ba85ae1e5c1 .

}

civic-kb:provenance-d409da7f061ef751522b2ba85ae1e5c1 {
	civic-kb:assertion-d409da7f061ef751522b2ba85ae1e5c1 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1 .

	civic-kb:Status-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-d409da7f061ef751522b2ba85ae1e5c1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-d409da7f061ef751522b2ba85ae1e5c1 {
	civic-kb:nanoPub-d409da7f061ef751522b2ba85ae1e5c1 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-d409da7f061ef751522b2ba85ae1e5c1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-e96185deedd330706810432a6325115a {
	civic-kb:nanoPub-e96185deedd330706810432a6325115a
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-e96185deedd330706810432a6325115a ;
		np:hasProvenance civic-kb:provenance-e96185deedd330706810432a6325115a ;
		np:hasPublicationInfo civic-kb:pubInfo-e96185deedd330706810432a6325115a .
}

civic-kb:assertion-e96185deedd330706810432a6325115a {
	civic-kb:Drugs-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e96185deedd330706810432a6325115a ;
		sio:hasValue	"Trastuzumab, Lapatinib"^^xsd:string .

	civic-kb:Status-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-e96185deedd330706810432a6325115a ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-e96185deedd330706810432a6325115a ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1008"^^xsd:integer .

	civic-kb:Gene-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-e96185deedd330706810432a6325115a ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"This Phase III trial compared the activity of lapatinib vs. trastuzumab vs. sequential trastuzumab followed by lapatinib vs. lapatinib plus trastuzumab in an adjuvant treatment setting.  8381 women were randomized to one of four treatment arms. Patients had HER2 positive non-metastatic operable BC. The primary endpoint was disease free survival.  First results report that after median 4.5 year follow up, a non significant 16% improvement in DFS was seen in trastuzumab + lapatinib vs. trastuzumab alone.  The results are interpreted as showing no added benefit for labatinib addition to trastuzumab in the adjuvant treatment context.  This trial is ongoing but not recruiting patients (NCT00490139)."^^xsd:string .

	civic-kb:Disease-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e96185deedd330706810432a6325115a ;
		rdf:type	efo:0000305 ;
		rdf:type	ncit:C4872 ;
		rdf:type	doid:1612 ;
		rdfs:label	"Breast Cancer"^^xsd:string ;
		sio:hasValue	"Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-e96185deedd330706810432a6325115a ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e96185deedd330706810432a6325115a ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e96185deedd330706810432a6325115a ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Does Not Support"^^xsd:string .

	civic-kb:Clinical_Significance-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-e96185deedd330706810432a6325115a ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-e96185deedd330706810432a6325115a	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-e96185deedd330706810432a6325115a ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-e96185deedd330706810432a6325115a	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-e96185deedd330706810432a6325115a .

}

civic-kb:provenance-e96185deedd330706810432a6325115a {
	civic-kb:assertion-e96185deedd330706810432a6325115a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-e96185deedd330706810432a6325115a .

	civic-kb:Status-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-e96185deedd330706810432a6325115a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-e96185deedd330706810432a6325115a {
	civic-kb:nanoPub-e96185deedd330706810432a6325115a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-e96185deedd330706810432a6325115a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-718faeb1f04ec43417a3768db942f609 {
	civic-kb:nanoPub-718faeb1f04ec43417a3768db942f609
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-718faeb1f04ec43417a3768db942f609 ;
		np:hasProvenance civic-kb:provenance-718faeb1f04ec43417a3768db942f609 ;
		np:hasPublicationInfo civic-kb:pubInfo-718faeb1f04ec43417a3768db942f609 .
}

civic-kb:assertion-718faeb1f04ec43417a3768db942f609 {
	civic-kb:Drugs-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-718faeb1f04ec43417a3768db942f609 ;
		sio:hasValue	"Trastuzumab, XL147 (Pilaralisib)"^^xsd:string .

	civic-kb:Status-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1448"^^xsd:integer .

	civic-kb:Gene-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In 5 trastuzumab resistant HER2 overexpressing breast cancer cell lines, combination of the pan-PI3K inhibitor XL147 and trastuzumab treatment induced cell death to similar or greater levels than XL147 alone. In three trastuzumab resistant cell lines tested, colony formation in matrigel was markedly inhibited by combination treatment. Apoptotic markers were apparent with combination treatment. In athymic mice, trastuzumab resistant cell line HR6 was used in tumor xenografts and tumors were allowed to form. Mice subsequently treated with trastuzumab or XL147 showed continued tumor growth without marked difference from control, while combination treatment essentially halted tumor growth rate."^^xsd:string .

	civic-kb:Disease-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-718faeb1f04ec43417a3768db942f609 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-718faeb1f04ec43417a3768db942f609 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-718faeb1f04ec43417a3768db942f609	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-718faeb1f04ec43417a3768db942f609 .

}

civic-kb:provenance-718faeb1f04ec43417a3768db942f609 {
	civic-kb:assertion-718faeb1f04ec43417a3768db942f609 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-718faeb1f04ec43417a3768db942f609 .

	civic-kb:Status-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-718faeb1f04ec43417a3768db942f609	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-718faeb1f04ec43417a3768db942f609 {
	civic-kb:nanoPub-718faeb1f04ec43417a3768db942f609 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-718faeb1f04ec43417a3768db942f609
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-f925694d5bc263de976b2dd16d1ca73d {
	civic-kb:nanoPub-f925694d5bc263de976b2dd16d1ca73d
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-f925694d5bc263de976b2dd16d1ca73d ;
		np:hasProvenance civic-kb:provenance-f925694d5bc263de976b2dd16d1ca73d ;
		np:hasPublicationInfo civic-kb:pubInfo-f925694d5bc263de976b2dd16d1ca73d .
}

civic-kb:assertion-f925694d5bc263de976b2dd16d1ca73d {
	civic-kb:Drugs-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-f925694d5bc263de976b2dd16d1ca73d ;
		rdf:type	dron:00730843 ;
		rdf:type	db:DB09074 ;
		rdfs:label	"Olaparib"^^xsd:string ;
		sio:hasValue	"Olaparib"^^xsd:string .

	civic-kb:Status-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"5816"^^xsd:integer .

	civic-kb:Gene-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18120 ;
		rdf:type	uniprot:P51587 ;
		rdfs:label	"BRCA2 Gene"^^xsd:string ;
		sio:hasValue	"BRCA2"^^xsd:string .

	civic-kb:Variant-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Loss of Function"^^xsd:string ;
		sio:hasValue	"LOSS-OF-FUNCTION"^^xsd:string .

	civic-kb:Description-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"302 patients (234 with progression events) with HER2-negative metastatic breast cancer and with a confirmed deleterious or suspected deleterious germline BRCA mutation (164 BRCA1, 129 BRCA2) had significantly improved progression-free survival and better response rate to olaparib (PARP inhibitor) than standard therapy (7.0 mo vs 4.2 mo, hazard ratio 0.58, 95% CI 0.43-0.8) in this randomized phase 3 trial (NCT02000622). For BRCA2 patients specifically, the hazard ratio was 0.68, 95% CI 0.45-0.1.07."^^xsd:string .

	civic-kb:Disease-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-f925694d5bc263de976b2dd16d1ca73d ;
		rdf:type	doid:0060080 ;
		rdfs:label	"Her2-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Germline Mutation"^^xsd:string .

	civic-kb:Trust_Rating-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-f925694d5bc263de976b2dd16d1ca73d .

}

civic-kb:provenance-f925694d5bc263de976b2dd16d1ca73d {
	civic-kb:assertion-f925694d5bc263de976b2dd16d1ca73d prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d .

	civic-kb:Status-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-f925694d5bc263de976b2dd16d1ca73d	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-f925694d5bc263de976b2dd16d1ca73d {
	civic-kb:nanoPub-f925694d5bc263de976b2dd16d1ca73d prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-f925694d5bc263de976b2dd16d1ca73d
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-8f83809a2cbb96d00d04869175ec71f1 {
	civic-kb:nanoPub-8f83809a2cbb96d00d04869175ec71f1
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-8f83809a2cbb96d00d04869175ec71f1 ;
		np:hasProvenance civic-kb:provenance-8f83809a2cbb96d00d04869175ec71f1 ;
		np:hasPublicationInfo civic-kb:pubInfo-8f83809a2cbb96d00d04869175ec71f1 .
}

civic-kb:assertion-8f83809a2cbb96d00d04869175ec71f1 {
	civic-kb:Drugs-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-8f83809a2cbb96d00d04869175ec71f1 ;
		rdf:type	dron:00018921 ;
		rdf:type	db:DB01259 ;
		rdfs:label	"Lapatinib"^^xsd:string ;
		sio:hasValue	"Lapatinib"^^xsd:string .

	civic-kb:Status-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"3052"^^xsd:integer .

	civic-kb:Gene-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Non-amplification"^^xsd:string ;
		sio:hasValue	"NON-AMPLIFICATION"^^xsd:string .

	civic-kb:Description-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string .

	civic-kb:Disease-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-8f83809a2cbb96d00d04869175ec71f1 ;
		rdf:type	doid:0060080 ;
		rdfs:label	"Her2-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-8f83809a2cbb96d00d04869175ec71f1 .

}

civic-kb:provenance-8f83809a2cbb96d00d04869175ec71f1 {
	civic-kb:assertion-8f83809a2cbb96d00d04869175ec71f1 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1 .

	civic-kb:Status-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-8f83809a2cbb96d00d04869175ec71f1	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-8f83809a2cbb96d00d04869175ec71f1 {
	civic-kb:nanoPub-8f83809a2cbb96d00d04869175ec71f1 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-8f83809a2cbb96d00d04869175ec71f1
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-47960bcc86cf902059e6a7330d4cd4f5 {
	civic-kb:nanoPub-47960bcc86cf902059e6a7330d4cd4f5
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-47960bcc86cf902059e6a7330d4cd4f5 ;
		np:hasProvenance civic-kb:provenance-47960bcc86cf902059e6a7330d4cd4f5 ;
		np:hasPublicationInfo civic-kb:pubInfo-47960bcc86cf902059e6a7330d4cd4f5 .
}

civic-kb:assertion-47960bcc86cf902059e6a7330d4cd4f5 {
	civic-kb:Drugs-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-47960bcc86cf902059e6a7330d4cd4f5 ;
		sio:hasValue	"Trastuzumab, Lapatinib"^^xsd:string .

	civic-kb:Status-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1008"^^xsd:integer .

	civic-kb:Gene-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"This Phase III trial compared the activity of lapatinib vs. trastuzumab vs. sequential trastuzumab followed by lapatinib vs. lapatinib plus trastuzumab in an adjuvant treatment setting.  8381 women were randomized to one of four treatment arms. Patients had HER2 positive non-metastatic operable BC. The primary endpoint was disease free survival.  First results report that after median 4.5 year follow up, a non significant 16% improvement in DFS was seen in trastuzumab + lapatinib vs. trastuzumab alone.  The results are interpreted as showing no added benefit for labatinib addition to trastuzumab in the adjuvant treatment context.  This trial is ongoing but not recruiting patients (NCT00490139)."^^xsd:string .

	civic-kb:Disease-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdf:type	efo:0000305 ;
		rdf:type	ncit:C4872 ;
		rdf:type	doid:1612 ;
		rdfs:label	"Breast Cancer"^^xsd:string ;
		sio:hasValue	"Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Does Not Support"^^xsd:string .

	civic-kb:Clinical_Significance-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-47960bcc86cf902059e6a7330d4cd4f5 .

}

civic-kb:provenance-47960bcc86cf902059e6a7330d4cd4f5 {
	civic-kb:assertion-47960bcc86cf902059e6a7330d4cd4f5 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5 .

	civic-kb:Status-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-47960bcc86cf902059e6a7330d4cd4f5	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-47960bcc86cf902059e6a7330d4cd4f5 {
	civic-kb:nanoPub-47960bcc86cf902059e6a7330d4cd4f5 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-47960bcc86cf902059e6a7330d4cd4f5
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-ba525e475aeaf55cb8ad15b76667e9a2 {
	civic-kb:nanoPub-ba525e475aeaf55cb8ad15b76667e9a2
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-ba525e475aeaf55cb8ad15b76667e9a2 ;
		np:hasProvenance civic-kb:provenance-ba525e475aeaf55cb8ad15b76667e9a2 ;
		np:hasPublicationInfo civic-kb:pubInfo-ba525e475aeaf55cb8ad15b76667e9a2 .
}

civic-kb:assertion-ba525e475aeaf55cb8ad15b76667e9a2 {
	civic-kb:Drugs-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-ba525e475aeaf55cb8ad15b76667e9a2 ;
		sio:hasValue	"Trastuzumab, XL147 (Pilaralisib)"^^xsd:string .

	civic-kb:Status-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1448"^^xsd:integer .

	civic-kb:Gene-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In 5 trastuzumab resistant HER2 overexpressing breast cancer cell lines, combination of the pan-PI3K inhibitor XL147 and trastuzumab treatment induced cell death to similar or greater levels than XL147 alone. In three trastuzumab resistant cell lines tested, colony formation in matrigel was markedly inhibited by combination treatment. Apoptotic markers were apparent with combination treatment. In athymic mice, trastuzumab resistant cell line HR6 was used in tumor xenografts and tumors were allowed to form. Mice subsequently treated with trastuzumab or XL147 showed continued tumor growth without marked difference from control, while combination treatment essentially halted tumor growth rate."^^xsd:string .

	civic-kb:Disease-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-ba525e475aeaf55cb8ad15b76667e9a2 .

}

civic-kb:provenance-ba525e475aeaf55cb8ad15b76667e9a2 {
	civic-kb:assertion-ba525e475aeaf55cb8ad15b76667e9a2 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2 .

	civic-kb:Status-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-ba525e475aeaf55cb8ad15b76667e9a2	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-ba525e475aeaf55cb8ad15b76667e9a2 {
	civic-kb:nanoPub-ba525e475aeaf55cb8ad15b76667e9a2 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-ba525e475aeaf55cb8ad15b76667e9a2
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-ed2a364a062f8d6f9ef41c8198434790 {
	civic-kb:nanoPub-ed2a364a062f8d6f9ef41c8198434790
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-ed2a364a062f8d6f9ef41c8198434790 ;
		np:hasProvenance civic-kb:provenance-ed2a364a062f8d6f9ef41c8198434790 ;
		np:hasPublicationInfo civic-kb:pubInfo-ed2a364a062f8d6f9ef41c8198434790 .
}

civic-kb:assertion-ed2a364a062f8d6f9ef41c8198434790 {
	civic-kb:Drugs-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-ed2a364a062f8d6f9ef41c8198434790 ;
		sio:hasValue	"Trastuzumab, LY294002"^^xsd:string .

	civic-kb:Status-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1455"^^xsd:integer .

	civic-kb:Gene-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18256 ;
		rdf:type	uniprot:P60484 ;
		rdfs:label	"PTEN Gene"^^xsd:string ;
		sio:hasValue	"PTEN"^^xsd:string .

	civic-kb:Variant-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Loss"^^xsd:string ;
		sio:hasValue	"LOSS"^^xsd:string .

	civic-kb:Description-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"Knockdown of PTEN in trastuzumab sensitive HER2 breast cancer BT474 cells induced trastuzumab resistance. PTEN null cells treated with PI3K inhibitor LY294002 also did not show substantial inhibition, but co-treatment with trastuzumab and LY294002 induced growth inhibition comparable to trastuzumab alone in normal BT474 cells. BT474 mouse xenograft tumors were injected with PTEN antisense (AS) oligonucleotides and this resulted in trastuzumab resitance. Co-treatment of PTEN AS tumor mice with LY294002 and trastuzumab inhibited tumor growth in comparison to PTEN AS tumors treated with trastuzumab or LY294002 alone."^^xsd:string .

	civic-kb:Disease-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-ed2a364a062f8d6f9ef41c8198434790 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-ed2a364a062f8d6f9ef41c8198434790 .

}

civic-kb:provenance-ed2a364a062f8d6f9ef41c8198434790 {
	civic-kb:assertion-ed2a364a062f8d6f9ef41c8198434790 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790 .

	civic-kb:Status-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-ed2a364a062f8d6f9ef41c8198434790	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-ed2a364a062f8d6f9ef41c8198434790 {
	civic-kb:nanoPub-ed2a364a062f8d6f9ef41c8198434790 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-ed2a364a062f8d6f9ef41c8198434790
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-e534046aade014e8733dc4a57bd401ae {
	civic-kb:nanoPub-e534046aade014e8733dc4a57bd401ae
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-e534046aade014e8733dc4a57bd401ae ;
		np:hasProvenance civic-kb:provenance-e534046aade014e8733dc4a57bd401ae ;
		np:hasPublicationInfo civic-kb:pubInfo-e534046aade014e8733dc4a57bd401ae .
}

civic-kb:assertion-e534046aade014e8733dc4a57bd401ae {
	civic-kb:Drugs-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e534046aade014e8733dc4a57bd401ae ;
		sio:hasValue	"Cisplatin, Carboplatin"^^xsd:string .

	civic-kb:Status-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1684"^^xsd:integer .

	civic-kb:Gene-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17965 ;
		rdf:type	uniprot:P38398 ;
		rdfs:label	"BRCA1 Gene"^^xsd:string ;
		sio:hasValue	"BRCA1"^^xsd:string .

	civic-kb:Variant-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18093 ;
		rdfs:label	"Mutation"^^xsd:string ;
		sio:hasValue	"MUTATION"^^xsd:string .

	civic-kb:Description-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In an evaluation of 77 patients, those who had BRCA1/2 germline mutations (n=11) had an increase response rate to cisplatin when compared to those without germline mutations (54.5% versus 19.7%; P=0.022) although progression free survival and overall survival was not significantly different."^^xsd:string .

	civic-kb:Disease-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-e534046aade014e8733dc4a57bd401ae ;
		rdf:type	efo:0005537 ;
		rdf:type	ncit:C71428 ;
		rdf:type	doid:60081 ;
		rdfs:label	"Triple-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Triple-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Germline Mutation"^^xsd:string .

	civic-kb:Trust_Rating-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-e534046aade014e8733dc4a57bd401ae ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-e534046aade014e8733dc4a57bd401ae	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-e534046aade014e8733dc4a57bd401ae .

}

civic-kb:provenance-e534046aade014e8733dc4a57bd401ae {
	civic-kb:assertion-e534046aade014e8733dc4a57bd401ae prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-e534046aade014e8733dc4a57bd401ae .

	civic-kb:Status-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-e534046aade014e8733dc4a57bd401ae	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-e534046aade014e8733dc4a57bd401ae {
	civic-kb:nanoPub-e534046aade014e8733dc4a57bd401ae prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-e534046aade014e8733dc4a57bd401ae
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-b3d194a0962ddb1250c9eca08c5b320a {
	civic-kb:nanoPub-b3d194a0962ddb1250c9eca08c5b320a
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-b3d194a0962ddb1250c9eca08c5b320a ;
		np:hasProvenance civic-kb:provenance-b3d194a0962ddb1250c9eca08c5b320a ;
		np:hasPublicationInfo civic-kb:pubInfo-b3d194a0962ddb1250c9eca08c5b320a .
}

civic-kb:assertion-b3d194a0962ddb1250c9eca08c5b320a {
	civic-kb:Drugs-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-b3d194a0962ddb1250c9eca08c5b320a ;
		rdf:type	dron:00730843 ;
		rdf:type	db:DB09074 ;
		rdfs:label	"Olaparib"^^xsd:string ;
		sio:hasValue	"Olaparib"^^xsd:string .

	civic-kb:Status-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1775"^^xsd:integer .

	civic-kb:Gene-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17965 ;
		rdf:type	uniprot:P38398 ;
		rdfs:label	"BRCA1 Gene"^^xsd:string ;
		sio:hasValue	"BRCA1"^^xsd:string .

	civic-kb:Variant-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18093 ;
		rdfs:label	"Mutation"^^xsd:string ;
		sio:hasValue	"MUTATION"^^xsd:string .

	civic-kb:Description-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In a study of 26 patients with breast cancer, 10 patients were BRCA-positive and 16 patients were BRCA-negative.  Regardless of BRCA status, none showed objective response when treated with olaparib."^^xsd:string .

	civic-kb:Disease-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-b3d194a0962ddb1250c9eca08c5b320a ;
		rdf:type	efo:0005537 ;
		rdf:type	ncit:C71428 ;
		rdf:type	doid:60081 ;
		rdfs:label	"Triple-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Triple-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Germline Mutation"^^xsd:string .

	civic-kb:Trust_Rating-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-b3d194a0962ddb1250c9eca08c5b320a .

}

civic-kb:provenance-b3d194a0962ddb1250c9eca08c5b320a {
	civic-kb:assertion-b3d194a0962ddb1250c9eca08c5b320a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a .

	civic-kb:Status-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-b3d194a0962ddb1250c9eca08c5b320a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-b3d194a0962ddb1250c9eca08c5b320a {
	civic-kb:nanoPub-b3d194a0962ddb1250c9eca08c5b320a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-b3d194a0962ddb1250c9eca08c5b320a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-544e9a83ab1b34dac2bb21000aaefac6 {
	civic-kb:nanoPub-544e9a83ab1b34dac2bb21000aaefac6
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-544e9a83ab1b34dac2bb21000aaefac6 ;
		np:hasProvenance civic-kb:provenance-544e9a83ab1b34dac2bb21000aaefac6 ;
		np:hasPublicationInfo civic-kb:pubInfo-544e9a83ab1b34dac2bb21000aaefac6 .
}

civic-kb:assertion-544e9a83ab1b34dac2bb21000aaefac6 {
	civic-kb:Drugs-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-544e9a83ab1b34dac2bb21000aaefac6 ;
		sio:hasValue	"Cisplatin, Carboplatin"^^xsd:string .

	civic-kb:Status-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1685"^^xsd:integer .

	civic-kb:Gene-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18120 ;
		rdf:type	uniprot:P51587 ;
		rdfs:label	"BRCA2 Gene"^^xsd:string ;
		sio:hasValue	"BRCA2"^^xsd:string .

	civic-kb:Variant-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18093 ;
		rdfs:label	"Mutation"^^xsd:string ;
		sio:hasValue	"MUTATION"^^xsd:string .

	civic-kb:Description-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In an evaluation of 77 patients, those who had BRCA1/2 germline mutations (n=11) had an increase response rate to cisplatin when compared to those without germline mutations (54.5% versus 19.7%; P=0.022) although progression free survival and overall survival was not significantly different."^^xsd:string .

	civic-kb:Disease-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdf:type	efo:0005537 ;
		rdf:type	ncit:C71428 ;
		rdf:type	doid:60081 ;
		rdfs:label	"Triple-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Triple-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Germline Mutation"^^xsd:string .

	civic-kb:Trust_Rating-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-544e9a83ab1b34dac2bb21000aaefac6 .

}

civic-kb:provenance-544e9a83ab1b34dac2bb21000aaefac6 {
	civic-kb:assertion-544e9a83ab1b34dac2bb21000aaefac6 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6 .

	civic-kb:Status-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-544e9a83ab1b34dac2bb21000aaefac6	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-544e9a83ab1b34dac2bb21000aaefac6 {
	civic-kb:nanoPub-544e9a83ab1b34dac2bb21000aaefac6 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-544e9a83ab1b34dac2bb21000aaefac6
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-830d708838f5ae804e949a73c380dc59 {
	civic-kb:nanoPub-830d708838f5ae804e949a73c380dc59
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-830d708838f5ae804e949a73c380dc59 ;
		np:hasProvenance civic-kb:provenance-830d708838f5ae804e949a73c380dc59 ;
		np:hasPublicationInfo civic-kb:pubInfo-830d708838f5ae804e949a73c380dc59 .
}

civic-kb:assertion-830d708838f5ae804e949a73c380dc59 {
	civic-kb:Drugs-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-830d708838f5ae804e949a73c380dc59 ;
		rdf:type	dron:00730843 ;
		rdf:type	db:DB09074 ;
		rdfs:label	"Olaparib"^^xsd:string ;
		sio:hasValue	"Olaparib"^^xsd:string .

	civic-kb:Status-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1776"^^xsd:integer .

	civic-kb:Gene-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18120 ;
		rdf:type	uniprot:P51587 ;
		rdfs:label	"BRCA2 Gene"^^xsd:string ;
		sio:hasValue	"BRCA2"^^xsd:string .

	civic-kb:Variant-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C18093 ;
		rdfs:label	"Mutation"^^xsd:string ;
		sio:hasValue	"MUTATION"^^xsd:string .

	civic-kb:Description-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In a study of 26 patients with breast cancer, 10 patients were BRCA-positive and 16 patients were BRCA-negative.  Regardless of BRCA status, none showed objective response when treated with olaparib."^^xsd:string .

	civic-kb:Disease-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-830d708838f5ae804e949a73c380dc59 ;
		rdf:type	efo:0005537 ;
		rdf:type	ncit:C71428 ;
		rdf:type	doid:60081 ;
		rdfs:label	"Triple-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Triple-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Germline Mutation"^^xsd:string .

	civic-kb:Trust_Rating-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-830d708838f5ae804e949a73c380dc59 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-830d708838f5ae804e949a73c380dc59	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-830d708838f5ae804e949a73c380dc59 .

}

civic-kb:provenance-830d708838f5ae804e949a73c380dc59 {
	civic-kb:assertion-830d708838f5ae804e949a73c380dc59 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-830d708838f5ae804e949a73c380dc59 .

	civic-kb:Status-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-830d708838f5ae804e949a73c380dc59	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-830d708838f5ae804e949a73c380dc59 {
	civic-kb:nanoPub-830d708838f5ae804e949a73c380dc59 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-830d708838f5ae804e949a73c380dc59
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-67c6ac2d1afd9d4c839ab8baced72904 {
	civic-kb:nanoPub-67c6ac2d1afd9d4c839ab8baced72904
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-67c6ac2d1afd9d4c839ab8baced72904 ;
		np:hasProvenance civic-kb:provenance-67c6ac2d1afd9d4c839ab8baced72904 ;
		np:hasPublicationInfo civic-kb:pubInfo-67c6ac2d1afd9d4c839ab8baced72904 .
}

civic-kb:assertion-67c6ac2d1afd9d4c839ab8baced72904 {
	civic-kb:Drugs-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdf:type	db:DB09073 ;
		rdfs:label	"Palbociclib"^^xsd:string ;
		sio:hasValue	"Palbociclib (PD0332991)"^^xsd:string .

	civic-kb:Status-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1629"^^xsd:integer .

	civic-kb:Gene-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C21412 ;
		rdf:type	uniprot:P24864 ;
		rdfs:label	"CCNE1 Gene"^^xsd:string ;
		sio:hasValue	"CCNE1"^^xsd:string .

	civic-kb:Variant-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string .

	civic-kb:Disease-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdf:type	efo:1000649 ;
		rdf:type	doid:0060075 ;
		rdfs:label	"Estrogen-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Estrogen-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-67c6ac2d1afd9d4c839ab8baced72904 .

}

civic-kb:provenance-67c6ac2d1afd9d4c839ab8baced72904 {
	civic-kb:assertion-67c6ac2d1afd9d4c839ab8baced72904 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904 .

	civic-kb:Status-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-67c6ac2d1afd9d4c839ab8baced72904	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-67c6ac2d1afd9d4c839ab8baced72904 {
	civic-kb:nanoPub-67c6ac2d1afd9d4c839ab8baced72904 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-67c6ac2d1afd9d4c839ab8baced72904
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-4994a3764221b6e7d0c69e244c84fd7a {
	civic-kb:nanoPub-4994a3764221b6e7d0c69e244c84fd7a
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-4994a3764221b6e7d0c69e244c84fd7a ;
		np:hasProvenance civic-kb:provenance-4994a3764221b6e7d0c69e244c84fd7a ;
		np:hasPublicationInfo civic-kb:pubInfo-4994a3764221b6e7d0c69e244c84fd7a .
}

civic-kb:assertion-4994a3764221b6e7d0c69e244c84fd7a {
	civic-kb:Drugs-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-4994a3764221b6e7d0c69e244c84fd7a ;
		sio:hasValue	"Trastuzumab, Trastuzumab Emtansine"^^xsd:string .

	civic-kb:Status-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"5817"^^xsd:integer .

	civic-kb:Gene-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"V777L"^^xsd:string ;
		sio:hasValue	"V777L"^^xsd:string .

	civic-kb:Description-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In a cohort of 205 Her2-receptor amplified breast cancers, 20 experienced recurrence after trastuzumab therapy. Of the 20 recurrent cases, only six patients had metastatic sites, excluding brain metastases, which were resistant to trastuzumab. NGS of thes six clinical specimens before and after trastuzumab therapy revealed one case of intrinsic activating mutation that leads to a valine-to-leucine substitution at codon 777 within the HER2 kinase domain (HER2 V777L)."^^xsd:string .

	civic-kb:Disease-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-4994a3764221b6e7d0c69e244c84fd7a ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"C"^^xsd:string .

	civic-kb:Evidence_Type-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Resistance or Non-Response"^^xsd:string .

	civic-kb:Variant_Origin-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-4994a3764221b6e7d0c69e244c84fd7a .

}

civic-kb:provenance-4994a3764221b6e7d0c69e244c84fd7a {
	civic-kb:assertion-4994a3764221b6e7d0c69e244c84fd7a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a .

	civic-kb:Status-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-4994a3764221b6e7d0c69e244c84fd7a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-4994a3764221b6e7d0c69e244c84fd7a {
	civic-kb:nanoPub-4994a3764221b6e7d0c69e244c84fd7a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-4994a3764221b6e7d0c69e244c84fd7a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-dc7b1a217ef35aba158b4e0cebf07179 {
	civic-kb:nanoPub-dc7b1a217ef35aba158b4e0cebf07179
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-dc7b1a217ef35aba158b4e0cebf07179 ;
		np:hasProvenance civic-kb:provenance-dc7b1a217ef35aba158b4e0cebf07179 ;
		np:hasPublicationInfo civic-kb:pubInfo-dc7b1a217ef35aba158b4e0cebf07179 .
}

civic-kb:assertion-dc7b1a217ef35aba158b4e0cebf07179 {
	civic-kb:Drugs-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdf:type	db:DB00997 ;
		rdfs:label	"Doxorubicin"^^xsd:string ;
		sio:hasValue	"Doxorubicin"^^xsd:string .

	civic-kb:Status-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"909"^^xsd:integer .

	civic-kb:Gene-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17801 ;
		rdf:type	uniprot:P11388 ;
		rdfs:label	"TOP2A Gene"^^xsd:string ;
		sio:hasValue	"TOP2A"^^xsd:string .

	civic-kb:Variant-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C16608 ;
		rdfs:label	"Expression"^^xsd:string ;
		sio:hasValue	"EXPRESSION"^^xsd:string .

	civic-kb:Description-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In a retrospective study, TOP2A expression was assessed by IHC for 108 breast cancer patients (from TAX 303 trial). TOP2A expression was associated with a higher probability of response in doxorubicin treated but not in docetaxel treated breast cancer patients."^^xsd:string .

	civic-kb:Disease-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdf:type	efo:0000305 ;
		rdf:type	ncit:C4872 ;
		rdf:type	doid:1612 ;
		rdfs:label	"Breast Cancer"^^xsd:string ;
		sio:hasValue	"Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"2"^^xsd:integer .

	civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-dc7b1a217ef35aba158b4e0cebf07179 .

}

civic-kb:provenance-dc7b1a217ef35aba158b4e0cebf07179 {
	civic-kb:assertion-dc7b1a217ef35aba158b4e0cebf07179 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179 .

	civic-kb:Status-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-dc7b1a217ef35aba158b4e0cebf07179	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-dc7b1a217ef35aba158b4e0cebf07179 {
	civic-kb:nanoPub-dc7b1a217ef35aba158b4e0cebf07179 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-dc7b1a217ef35aba158b4e0cebf07179
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-1a5d993e22f1ee96a43c6f6363392a6a {
	civic-kb:nanoPub-1a5d993e22f1ee96a43c6f6363392a6a
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-1a5d993e22f1ee96a43c6f6363392a6a ;
		np:hasProvenance civic-kb:provenance-1a5d993e22f1ee96a43c6f6363392a6a ;
		np:hasPublicationInfo civic-kb:pubInfo-1a5d993e22f1ee96a43c6f6363392a6a .
}

civic-kb:assertion-1a5d993e22f1ee96a43c6f6363392a6a {
	civic-kb:Drugs-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-1a5d993e22f1ee96a43c6f6363392a6a ;
		sio:hasValue	"Palbociclib (PD0332991), Letrozole"^^xsd:string .

	civic-kb:Status-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1765"^^xsd:integer .

	civic-kb:Gene-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18022 ;
		rdf:type	uniprot:P42771 ;
		rdfs:label	"CDKN2A Gene"^^xsd:string ;
		sio:hasValue	"CDKN2A"^^xsd:string .

	civic-kb:Variant-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Loss"^^xsd:string ;
		sio:hasValue	"LOSS"^^xsd:string .

	civic-kb:Description-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"A patient with metastatic ER-positive, her2-negative breast cancer with CDKN2A loss experienced a short-lived (~3-month) clinical response to palbociclib when given in combination with letrozole."^^xsd:string .

	civic-kb:Disease-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdf:type	doid:0060080 ;
		rdfs:label	"Her2-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"C"^^xsd:string .

	civic-kb:Evidence_Type-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-1a5d993e22f1ee96a43c6f6363392a6a .

}

civic-kb:provenance-1a5d993e22f1ee96a43c6f6363392a6a {
	civic-kb:assertion-1a5d993e22f1ee96a43c6f6363392a6a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a .

	civic-kb:Status-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-1a5d993e22f1ee96a43c6f6363392a6a	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-1a5d993e22f1ee96a43c6f6363392a6a {
	civic-kb:nanoPub-1a5d993e22f1ee96a43c6f6363392a6a prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-1a5d993e22f1ee96a43c6f6363392a6a
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-404be39b576364135de588d92d5ac67b {
	civic-kb:nanoPub-404be39b576364135de588d92d5ac67b
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-404be39b576364135de588d92d5ac67b ;
		np:hasProvenance civic-kb:provenance-404be39b576364135de588d92d5ac67b ;
		np:hasPublicationInfo civic-kb:pubInfo-404be39b576364135de588d92d5ac67b .
}

civic-kb:assertion-404be39b576364135de588d92d5ac67b {
	civic-kb:Drugs-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-404be39b576364135de588d92d5ac67b ;
		rdf:type	dron:00730843 ;
		rdf:type	db:DB09074 ;
		rdfs:label	"Olaparib"^^xsd:string ;
		sio:hasValue	"Olaparib"^^xsd:string .

	civic-kb:Status-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"5816"^^xsd:integer .

	civic-kb:Gene-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C18120 ;
		rdf:type	uniprot:P51587 ;
		rdfs:label	"BRCA2 Gene"^^xsd:string ;
		sio:hasValue	"BRCA2"^^xsd:string .

	civic-kb:Variant-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Loss of Function"^^xsd:string ;
		sio:hasValue	"LOSS-OF-FUNCTION"^^xsd:string .

	civic-kb:Description-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"302 patients (234 with progression events) with HER2-negative metastatic breast cancer and with a confirmed deleterious or suspected deleterious germline BRCA mutation (164 BRCA1, 129 BRCA2) had significantly improved progression-free survival and better response rate to olaparib (PARP inhibitor) than standard therapy (7.0 mo vs 4.2 mo, hazard ratio 0.58, 95% CI 0.43-0.8) in this randomized phase 3 trial (NCT02000622). For BRCA2 patients specifically, the hazard ratio was 0.68, 95% CI 0.45-0.1.07."^^xsd:string .

	civic-kb:Disease-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-404be39b576364135de588d92d5ac67b ;
		rdf:type	doid:0060080 ;
		rdfs:label	"Her2-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Germline Mutation"^^xsd:string .

	civic-kb:Trust_Rating-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-404be39b576364135de588d92d5ac67b ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-404be39b576364135de588d92d5ac67b	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-404be39b576364135de588d92d5ac67b .

}

civic-kb:provenance-404be39b576364135de588d92d5ac67b {
	civic-kb:assertion-404be39b576364135de588d92d5ac67b prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-404be39b576364135de588d92d5ac67b .

	civic-kb:Status-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-404be39b576364135de588d92d5ac67b	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-404be39b576364135de588d92d5ac67b {
	civic-kb:nanoPub-404be39b576364135de588d92d5ac67b prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-404be39b576364135de588d92d5ac67b
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-95e00edcde6727ca5a38c46ca58cb859 {
	civic-kb:nanoPub-95e00edcde6727ca5a38c46ca58cb859
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-95e00edcde6727ca5a38c46ca58cb859 ;
		np:hasProvenance civic-kb:provenance-95e00edcde6727ca5a38c46ca58cb859 ;
		np:hasPublicationInfo civic-kb:pubInfo-95e00edcde6727ca5a38c46ca58cb859 .
}

civic-kb:assertion-95e00edcde6727ca5a38c46ca58cb859 {
	civic-kb:Drugs-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-95e00edcde6727ca5a38c46ca58cb859 ;
		rdf:type	dron:00018921 ;
		rdf:type	db:DB01259 ;
		rdfs:label	"Lapatinib"^^xsd:string ;
		sio:hasValue	"Lapatinib"^^xsd:string .

	civic-kb:Status-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"submitted"^^xsd:string .

	civic-kb:Evidence_ID-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"3052"^^xsd:integer .

	civic-kb:Gene-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdfs:label	"Non-amplification"^^xsd:string ;
		sio:hasValue	"NON-AMPLIFICATION"^^xsd:string .

	civic-kb:Description-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string .

	civic-kb:Disease-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-95e00edcde6727ca5a38c46ca58cb859 ;
		rdf:type	doid:0060080 ;
		rdfs:label	"Her2-receptor Negative Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Negative Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string .

	civic-kb:Trust_Rating-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"3"^^xsd:integer .

	civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-95e00edcde6727ca5a38c46ca58cb859 .

}

civic-kb:provenance-95e00edcde6727ca5a38c46ca58cb859 {
	civic-kb:assertion-95e00edcde6727ca5a38c46ca58cb859 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859 .

	civic-kb:Status-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-95e00edcde6727ca5a38c46ca58cb859	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-95e00edcde6727ca5a38c46ca58cb859 {
	civic-kb:nanoPub-95e00edcde6727ca5a38c46ca58cb859 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-95e00edcde6727ca5a38c46ca58cb859
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-d29a96a9b9e3b29ae8f18f38ae0ca249 {
	civic-kb:nanoPub-d29a96a9b9e3b29ae8f18f38ae0ca249
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		np:hasProvenance civic-kb:provenance-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		np:hasPublicationInfo civic-kb:pubInfo-d29a96a9b9e3b29ae8f18f38ae0ca249 .
}

civic-kb:assertion-d29a96a9b9e3b29ae8f18f38ae0ca249 {
	civic-kb:Drugs-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		sio:hasValue	"Trastuzumab, Lapatinib"^^xsd:string .

	civic-kb:Status-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1008"^^xsd:integer .

	civic-kb:Gene-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"This Phase III trial compared the activity of lapatinib vs. trastuzumab vs. sequential trastuzumab followed by lapatinib vs. lapatinib plus trastuzumab in an adjuvant treatment setting.  8381 women were randomized to one of four treatment arms. Patients had HER2 positive non-metastatic operable BC. The primary endpoint was disease free survival.  First results report that after median 4.5 year follow up, a non significant 16% improvement in DFS was seen in trastuzumab + lapatinib vs. trastuzumab alone.  The results are interpreted as showing no added benefit for labatinib addition to trastuzumab in the adjuvant treatment context.  This trial is ongoing but not recruiting patients (NCT00490139)."^^xsd:string .

	civic-kb:Disease-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdf:type	efo:0000305 ;
		rdf:type	ncit:C4872 ;
		rdf:type	doid:1612 ;
		rdfs:label	"Breast Cancer"^^xsd:string ;
		sio:hasValue	"Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"B"^^xsd:string .

	civic-kb:Evidence_Type-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Does Not Support"^^xsd:string .

	civic-kb:Clinical_Significance-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-d29a96a9b9e3b29ae8f18f38ae0ca249 .

}

civic-kb:provenance-d29a96a9b9e3b29ae8f18f38ae0ca249 {
	civic-kb:assertion-d29a96a9b9e3b29ae8f18f38ae0ca249 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249 .

	civic-kb:Status-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-d29a96a9b9e3b29ae8f18f38ae0ca249	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-d29a96a9b9e3b29ae8f18f38ae0ca249 {
	civic-kb:nanoPub-d29a96a9b9e3b29ae8f18f38ae0ca249 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-d29a96a9b9e3b29ae8f18f38ae0ca249
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}

civic-kb:head-256018214dd777f21fd2aa2bccd02c81 {
	civic-kb:nanoPub-256018214dd777f21fd2aa2bccd02c81
		rdf:type np:Nanopublication ;
		np:hasAssertion civic-kb:assertion-256018214dd777f21fd2aa2bccd02c81 ;
		np:hasProvenance civic-kb:provenance-256018214dd777f21fd2aa2bccd02c81 ;
		np:hasPublicationInfo civic-kb:pubInfo-256018214dd777f21fd2aa2bccd02c81 .
}

civic-kb:assertion-256018214dd777f21fd2aa2bccd02c81 {
	civic-kb:Drugs-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Drugs ;
		rdf:type	sio:Drug ;
		rdfs:label "Drugs"^^xsd:string ;
		rdfs:comment "Drugs"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-256018214dd777f21fd2aa2bccd02c81 ;
		sio:hasValue	"Trastuzumab, XL147 (Pilaralisib)"^^xsd:string .

	civic-kb:Status-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Status ;
		rdf:type	sio:StatusDescriptor ;
		sio:isAttributeOf civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Status"^^xsd:string ;
		rdfs:comment "Status"^^xsd:string ;
		sio:hasValue	"accepted"^^xsd:string .

	civic-kb:Evidence_ID-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Evidence_ID ;
		rdf:type	sio:Identifier ;
		sio:isAttributeOf civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Evidence ID"^^xsd:string ;
		rdfs:comment "Evidence ID"^^xsd:string ;
		sio:hasValue	"1448"^^xsd:integer .

	civic-kb:Gene-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Gene ;
		rdf:type	sio:Gene ;
		rdfs:label "Gene"^^xsd:string ;
		rdfs:comment "Gene"^^xsd:string ;
		rdf:type	ncit:C17756 ;
		rdf:type	uniprot:P04626 ;
		rdfs:label	"ERBB2 Gene"^^xsd:string ;
		sio:hasValue	"ERBB2"^^xsd:string .

	civic-kb:Variant-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Variant ;
		rdf:type	ncit:C97927 ;
		rdfs:label "Variant"^^xsd:string ;
		rdfs:comment "Variant"^^xsd:string ;
		sio:hasRole [ rdf:type	sio:VariantRole ;
			sio:inRelationTo civic-kb:Gene ] ;
		rdf:type	ncit:C45581 ;
		rdfs:label	"Amplification"^^xsd:string ;
		sio:hasValue	"AMPLIFICATION"^^xsd:string .

	civic-kb:Description-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Description ;
		rdf:type	sio:Description ;
		sio:isAttributeOf civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Description"^^xsd:string ;
		rdfs:comment "Description"^^xsd:string ;
		sio:hasValue	"In 5 trastuzumab resistant HER2 overexpressing breast cancer cell lines, combination of the pan-PI3K inhibitor XL147 and trastuzumab treatment induced cell death to similar or greater levels than XL147 alone. In three trastuzumab resistant cell lines tested, colony formation in matrigel was markedly inhibited by combination treatment. Apoptotic markers were apparent with combination treatment. In athymic mice, trastuzumab resistant cell line HR6 was used in tumor xenografts and tumors were allowed to form. Mice subsequently treated with trastuzumab or XL147 showed continued tumor growth without marked difference from control, while combination treatment essentially halted tumor growth rate."^^xsd:string .

	civic-kb:Disease-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Disease ;
		rdf:type	sio:Disease ;
		rdfs:label "Disease"^^xsd:string ;
		rdfs:comment "Disease"^^xsd:string ;
		sio:inRelationTo	civic-kb:Gene-256018214dd777f21fd2aa2bccd02c81 ;
		rdf:type	efo:1000294 ;
		rdf:type	ncit:C53556 ;
		rdf:type	doid:0060079 ;
		rdfs:label	"Her2-receptor Positive Breast Cancer"^^xsd:string ;
		sio:hasValue	"Her2-receptor Positive Breast Cancer"^^xsd:string .

	civic-kb:Evidence_Level-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Evidence_Level ;
		rdf:type	ncit:C25554 ;
		sio:isAttributeOf civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Evidence Level"^^xsd:string ;
		rdfs:comment "Evidence Level"^^xsd:string ;
		sio:hasValue	"D"^^xsd:string .

	civic-kb:Evidence_Type-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Evidence_Type ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Evidence Type"^^xsd:string ;
		rdfs:comment "Evidence Type"^^xsd:string ;
		sio:hasValue	"Predictive"^^xsd:string .

	civic-kb:Evidence_Direction-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Evidence_Direction ;
		rdf:type	sio:Attribute ;
		sio:isAttributeOf civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Evidence Direction"^^xsd:string ;
		rdfs:comment "Evidence Direction"^^xsd:string ;
		sio:hasValue	"Supports"^^xsd:string .

	civic-kb:Clinical_Significance-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Clinical_Significance ;
		rdf:type	sio:Attribute ;
		rdfs:label "Clinical Significance"^^xsd:string ;
		rdfs:comment "Clinical Significance"^^xsd:string ;
		sio:hasValue	"Sensitivity"^^xsd:string .

	civic-kb:Variant_Origin-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Variant_Origin ;
		rdf:type	ncit:C42703 ;
		sio:isAttributeOf civic-kb:Variant-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Variant Origin"^^xsd:string ;
		rdfs:comment "Variant Origin"^^xsd:string ;
		sio:hasValue	"Somatic Mutation"^^xsd:string .

	civic-kb:Trust_Rating-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:Trust_Rating ;
		rdf:type	ncit:C77538 ;
		sio:isAttributeOf civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 ;
		rdfs:label "Trust Rating"^^xsd:string ;
		rdfs:comment "Trust Rating"^^xsd:string ;
		sio:hasValue	"4"^^xsd:integer .

	civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81	rdf:type	civic-kb:evidence;
		rdf:type	ncit:C43583;
		sio:hasIdentifier civic-kb:Evidence_ID-256018214dd777f21fd2aa2bccd02c81 .

}

civic-kb:provenance-256018214dd777f21fd2aa2bccd02c81 {
	civic-kb:assertion-256018214dd777f21fd2aa2bccd02c81 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  ;
		prov:wasDerivedFrom	civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81 .

	civic-kb:Status-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_ID-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Gene-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Description-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Disease-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Level-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Type-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Evidence_Direction-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Clinical_Significance-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Variant_Origin-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:Trust_Rating-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

	civic-kb:evidence-256018214dd777f21fd2aa2bccd02c81	prov:generatedAtTime	"2018-03-05T19:54:48Z"^^xsd:dateTime  .

}

civic-kb:pubInfo-256018214dd777f21fd2aa2bccd02c81 {
	civic-kb:nanoPub-256018214dd777f21fd2aa2bccd02c81 prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime .

	civic-kb:Drugs-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"1"^^xsd:integer .

	civic-kb:Status-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"2"^^xsd:integer .

	civic-kb:Evidence_ID-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"3"^^xsd:integer .

	civic-kb:Gene-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"4"^^xsd:integer .

	civic-kb:Variant-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"5"^^xsd:integer .

	civic-kb:Description-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"6"^^xsd:integer .

	civic-kb:Disease-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"7"^^xsd:integer .

	civic-kb:Evidence_Level-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"8"^^xsd:integer .

	civic-kb:Evidence_Type-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"9"^^xsd:integer .

	civic-kb:Evidence_Direction-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"10"^^xsd:integer .

	civic-kb:Clinical_Significance-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"11"^^xsd:integer .

	civic-kb:Variant_Origin-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"12"^^xsd:integer .

	civic-kb:Trust_Rating-256018214dd777f21fd2aa2bccd02c81
		prov:generatedAtTime "2018-03-05T19:54:48Z"^^xsd:dateTime ;
		hasco:hasPosition	"13"^^xsd:integer .

}